Placebo-Controlled Trial of Ketanserin in the Treatment of Intermittent Claudication

Cameron, H. A.; Waller, P. C.; Ramsay, L. E.
July 1987
Angiology;Jul1987, Vol. 38 Issue 7, p549
Academic Journal
The effect of ketanserin on the symptoms of 21 patients with stable intermittent claudication was examined in a double-blind, placebo-controlled, parallel-group study. Benefit was assessed by repeated treadmill exercise tests, recording claudication and total walking times. After three months' treatment with ketanserin (mean dose 167 mg/day) there was no significant change in claudication time (mean change +12%, 95% CI -9 ; +33%) or total walking time (mean change -14%, 95% CI -47%; +19%). The confidence intervals show that ketanserin treatment is unlikely to be associated with clinically important improvement.


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