Effects of Pentoxifylline and Prostaglandin E1 on Cold Blood Perfusion Studied by Red Blood Cell Deformability

Sakai, Akira; Kikuchi, Yuji; Ohshima, Norio; Hori, Motokazu
July 1987
Angiology;Jul1987, Vol. 38 Issue 7, p514
Academic Journal
The effects of pentoxifylline and prostaglandin E1 (PGE1) on red blood cell deformability during cold blood perfusion were studied by means of a filtration method. The deformability of normal red blood cells decreased with the temperature transition from 20° to 15°C (transit time: 3.5, 5.8, 25, and 99 seconds at 37°, 20°, 15°, and 10°C respectively). The effects of both pentoxifylline and PGE1 were not noticeable at 37°C but became significant with hypothermia (5.0, 12, and 48 seconds at 20°, 15°, and 10°C, respectively, in samples with pentoxifylline of 0.3 mg/ml; 5.3, 13, and 46 seconds at 20°, 15°, and 10°C, respectively, in those with PGE1 of 40 ng/ml). The results in this study suggest that pretreatment of blood by pentoxifylline or PGE1 could improve coronary microcirculation perfused with cold blood cardioplegic solutions owing to significant improvement of the deformability of red blood cells.


Related Articles

  • Effect of Pentoxifylline on Microvascular Blood Flow Velocity. Ohshima, Norio; Sato, Masaaki // Angiology;Nov1981, Vol. 32 Issue 11, p752 

    Pentoxifylline (PF), known to increase red blood cell (RBC) deformability, has recently attracted much attention because of its possible effect of reducing capillary resistance. There has been practically no reliable demonstration of an increase in capillary blood flow by this drug. This study...

  • Skin Oxygen Pressure Histograms in Patients with Peripheral Arterial Occlusive Disease During Intraarterial and Intravenous Prostaglandin E&sub1; Infusions of Different Dosages and Their Prognostic Value. Creutzig, Andreas; Arnold, Andreas; Caspary, Ludwig; Thum, Joachim; Alexander, Klaus // Angiology;May1995, Vol. 46 Issue 5, p357 

    Skin surface oxygen pressure fields (tcPO2 [37�C]) reproducibly characterize skin microcirculation in patients with peripheral arterial occlusive disease. These appear suited for investigation of short- and long-term effects of vasoactive drug treatment. The authors studied whether skin...

  • Effect of Pentoxifylline on the Flow of Polymorphonuclear Leukocytes Through a Model Capillary. Armstrong Jr., Michael; Needham, David; Hatchell, Diane Lillian; Nunn, Rashmi Saxena // Angiology;Apr1990, Vol. 41 Issue 4, p253 

    Pentoxifylline is a methylxanthine derivative used to increase blood flow in peripheral atherosclerosis. Pentoxifylline is known to increase whole blood filtration rate, and recent evidence suggests that pentoxifylline increases the filtration rate of polymorphonuclear leukocytes (PMNs). The...

  • Splanchnic erythrocyte content decreases during hemodialysis: A new compensatory mechanism for hypovolemia. Yu, Alex W.; Nawab, Zeenat M.; Barnes, W. Earl; Lai, Kai N.; Ing, Todd S.; Daugirdas, John T. // Kidney International;Jun1997, Vol. 51 Issue 6, p1986 

    Splanchnic and splenic erythrocyte volumes decrease during postural changes and exercise to help maintain central blood volume and cardiac output. The contribution of this compensatory mechanism to hemodynamic stability during dialysis has not been studied, however. In 8 ESRD patients, age ...

  • Tribology of capillary blood flow. Secomb, T. W.; Hsu, R.; Pries, A. R. // Proceedings of the Institution of Mechanical Engineers -- Part J;Dec2006, Vol. 220 Issue 8, p767 

    The capillaries, with diameters typically in the range of 4 to 8 �m, are the terminal branches of the circulatory system. Blood is a concentrated suspension, containing 40-45 per cent volume of red blood cells (erythrocytes) suspended in plasma. These cells must undergo large deformations...

  • Effect of Deformation of Red Cell on Nutritional Transport in Capillary-Tissue Exchange System. Bali, Rekha; Mishra, Swati; Mishra, Mamta // Applied Mathematics;Nov2011, Vol. 2 Issue 11, p1417 

    A mathematical analysis of a model for nutritional exchange in a capillary-tissue exchange system is presented in this paper. This model consists of a single file flow of red blood cell in capillary when diameter of red blood cell is greater than tube diameter. In this case, the cell must be...

  • Doppler Spectroscopy of Blood In Vivo under the Action of Low-Intensity Laser Radiation. Korolevich, A. N.; Astaf'eva, L. G.; Dubina, N. S.; Vecherinski&icaron;, S. I.; Belsley, M. S. // Optics & Spectroscopy;Mar2004, Vol. 96 Issue 3, p458 

    The rate of microcirculation of blood in human skin is studied in vivo in the normal state and in the presence of cardiovascular diseases. It is shown experimentally that low-intensity laser radiation affects the rheological characteristics of erythrocytes. To explain the results obtained, a...

  • Renal cortical and medullary microvascular blood flow autoregulation in rat. Harrison-Bernard, Lisa M.; Navar, L. Gabriel; Cook, Anthony K. // Kidney International Supplement;Dec1996, Issue 57, pS-23 

    Previous studies have demonstrated the critical role of the afferent arteriole in autoregulation of nephron blood How in response to changes in perfusion pressure. The present study focused tin the responses of postglomerular vascular segments to alterations in renal arterial pressure. Afferent...

  • Red Blood Cells Motion in a Glass Microchannel. Pinho, Diana; Pereira, Ana I.; Lima, Rui // AIP Conference Proceedings;9/30/2010, Vol. 1281 Issue 1, p963 

    The motion of the red blood cells (RBCs) flowing in microvessels and microchannels depend on several effects, such as hematocrit (Hct), geometry, and temperature. According to our knowledge, the effect of the temperature on RBC motion was never investigated at a microscale level. Hence, the aim...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics