Strandness Jr., D. E.; Summer, D. S.
February 1975
Angiology;Feb1975, Vol. 26 Issue 2, p187
Academic Journal
The diagnosis of peripheral atherosclerosis can be objectively established and followed by a variety of noninvasive methods. The techniques include measurements of limb blood pressure and flow under resting conditions and following periods of stress, such as exercise or during reactive hyperemia produced by cuff occlusion of arterial inflow. These methods have been shown to be accurate, reproducible and applicable for long-term studies. While it is not yet established "how early" peripheral atherosclerosis can be detected, it is certain that disease can be objectively demonstrated before symptoms develop. The ultrasonic arteriogram shows great promise for noninvasive evaluation of arterial geometry at selected sites, such as the carotid, femoral and popliteal arteries. Plaques a few millimeters in height can be demonstrated by this method. This technique may be useful to determine to what extent established lesions can or will regress with institution of therapy when it becomes available. Technology and experience is already available to permit institution of studies of large groups of patients to assess the incidence of the disease as related to known risk factors. Furthermore, as methods of therapy are proposed and instituted, these methods may be used to objectively assess the results of such treatment in arresting the disease and promoting regression of existing lesions.


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