Intrapericardial Instillation of Sodium Hydroxide: Failure to Produce Pericardial Symphysis

Srinivasan, Venkatraman; Berdoff, Russell L.; Goldberg, Emanuel; Gallerstein, Peter E.; Ehya, Hormoz; Berger, Marvin
January 1984
Angiology;Jan1984, Vol. 35 Issue 1, p22
Academic Journal
Previously reported clinical studies have suggested sodium hydroxide as an effective agent in causing pleural symphysis. To explore the sclerosing potential of this agent, we instilled 0.5% sodium hydroxide into the pericardium of four dogs. Normal saline was instilled into the pericardium of one control dog. Echocardiograms. 24 hour EKG monitoring and intracardiac pressures were recorded. One dog was sacrificed at the end of 24 hours, another at the end of seven days and three other dogs were sacrificed at the end of 28 days. ST elevations and prolonged episodes of supra-ventricular and ventricular tachycardia were noted during and within 24 hours after the intrapericardial instillation of sodium hydroxide in all the dogs. No arrhythmias were noted in the control dog. None of the dogs showed pericardial symphysis. These results suggest that sodium hydroxide causes serious cardiac arrhythmias when instilled intrapericardially and is of limited value in causing pericardial symphysis.


Related Articles

  • Intracardiac Electrocardiography in the Analysis and Understanding of Cardiac Arrhythmias. Goldreyer, Bruce N. // Annals of Internal Medicine;Jul72, Vol. 77 Issue 1, p117 

    Focuses on a study which analyzed cardiac arrhythmias using intracardiac electrocardiography. Mechanism of paroxysmal supraventricular tachycardia; Mechanism of flutter and fibrillation; Electrocardiographic diagnosis of ventricular tachycardia.

  • Hyperkalemia Revisited. Parham, Walter A.; Mehdirad, Ali A.; Biermann, Kurt M.; Fredman, Carey S. // Texas Heart Institute Journal;2006, Vol. 33 Issue 1, p40 

    Hyperkalemia is a common clinical condition that can induce deadly cardiac arrhythmias. Electrocardiographic manifestations of hyperkalemia vary from the classic sine-wave rhythm, which occurs in severe hyperkalemia, to nonspecific repolarization abnormalities seen with mild elevations of serum...

  • Characteristics of physiological responses to +Gx loads in non-professional crew members of short-term missions to the ISS. Kotovskaya, A.; Vil'-Vil'yams, I. // Human Physiology;Dec2011, Vol. 37 Issue 7, p810 

    Analysis of physiological responses to +Gx loads during space flights (SFs) 8-12 days in duration was carried out in ten non-professional crew members of the International Space Station (ISS), many of whom were accepted to participate in SFs while having partial health deficiency. The results...

  • Paroxysmal Ventricular Tachycardia in the Absence of Organic Heart Disease. Lesch, Michael; Lewis, Edmund; Humphries, J. O'Neal; Ross, Richard S. // Annals of Internal Medicine;May67, Vol. 66 Issue 5, p950 

    Details the case of woman who had no organic heart disease but was disabled by paroxysms of ventricular tachycardia. Clinical features of the patient with paroxysmal ventricular tachycardia; Details of the rhythm and pattern of the electrocardiogram of the patient; Types of arrhythmia.

  • PSEUDOTACHYCARDIA DURING 24-HOUR ELECTROCARDIOGRAPHS MONITORING. Kleid, Jack J.; Naidu, Sriramalu; Benda, Richard; Cagin, Norman A.; Levitt, Barrie // Angiology;Apr1977, Vol. 28 Issue 4, p282 

    Describes a clinical case in which a tachycardia was spuriously recorded as a result of insufficient battery voltage. Acceptance of round-the-clock electrocardiographic monitoring as a tool in detecting arrhythmias and electrocardiographic changes in the ambulatory patient; Observation that...

  • Supraventricular Tachycardia: Mechanisms and Management. Josephson, Mark E.; Kastor, John A. // Annals of Internal Medicine;Sep77, Vol. 87 Issue 3, p346 

    The phrase paroxysmal supraventricular tachycardia describes a group of arrhythmias with similar electrocardiographic features but different mechanisms that have been clarified in recent years with specialized intracardiac recording and pacing techniques. Reentry accounts for most cases and has...

  • Country cardiograms case 30: Answer. Helm, Charles // Canadian Journal of Rural Medicine;Winter2006 Supplement, Vol. 11, p133 

    The article interprets the country cardiograms case 30, which involves a display of a wide complex tachycardia. Based from the illustration presented through patient information, the QRS complex merges with the downsloping ST segment and deeply inverted T waves, as often happens with this kind...

  • Ventricular Arrhythmias Induced by Programmed Ventricular Stimulation After Uncomplicated Myocardial Infarction. Hueb, Whady; Bellotti, Giovanni; Sosa, Eduardo; Ramires, Jos� Antonio; da Luz, Protasio Lemos; Pileggi, Fulvio // Angiology;Jul1992, Vol. 43 Issue 7, p578 

    The aim of this study was to correlate the occurrence of ventricular dysrhythmias induced by programmed ventricular stimulation and sudden cardiac death (SCD) after a first episode of acute myocardial infarction (AMI). Twenty-seven consecutive male patients aged fifty-four� six (forty-seven...

  • Use of the Electrocardiogram in Acute Myocardial Infarction. Zimetbaum, Peter J.; Josephson, Mark E. // New England Journal of Medicine;3/6/2003, Vol. 348 Issue 10, p933 

    Examines the use of the electrocardiogram in acute myocardial infarction. Importance of electrocardiograms as a tool in the identification and management of acute myocardial infarction; Identification of the infarct-related artery; Arrhythmias and conduction disease in acute myocardial...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics