Voudoukis, Ignatios J.
January 1975
Angiology;Jan1975 Part 1, Vol. 26 Issue 1, p54
Academic Journal
In summary, a prognostic and therapeutic evaluation of 227 patients first seen from 1967 to the end of 1969 with a follow-up of 4–7 years was made. The results are indeed depressing. In spite of close follow-up and systematic treatment with modern antihypertensive agents, the mortality of patients having hypertension with superimposed arteriosclerosis was 27% (15 to 56) for males as contrasted to 3% (2 of 75) for females. Since the last casual blood pressure in both living and deceased patients of the mixed group were similar, the level of blood pressure following treatment could not be incriminated for the deceased patients. An exaggerated systolic and pulse pressure cold pressor response emerged as an important indicator of presence of arteriosclerosis alone. When hypertension and arteriosclerosis coexisted there was also exaggeration in diastolic cold pressor response. A further exaggeration in systolic and diastolic cold pressor response was seen in the deceased as compared to living male patients, a finding which appears to have grave prognostic significance for coronary heart disease and stroke. Thus a marked exaggeration in both systolic and diastolic cold pressor response in males might prove to be the single most important predictor of premature death from atherosclerotic vascular disease. A further analysis of the deceased male patients having hypertension and superimposed arteriosclerosis, indicates that treatment of hypertension may prevent death from stroke but not from coronary heart disease. Two-thirds of the deaths occur suddenly and only one-third of the deceased patients reach the hospital before dying. In view of these distressing findings a plea for early detection and treatment of hypertension, prior to the development of superimposed arteriosclerotic changes, particularly in males, is made.


Related Articles

  • NICE signals significant changes in BP guidance.  // Pulse;11/5/2005, Vol. 65 Issue 43, p4 

    Reports on the study which found that the ASCOT trial is likely to have a significant impact on new NICE and British Hypertension Society guidelines for hypertension in Great Britain. Confirmation of the need for a wider evaluation of hypertension guidance; Improvement of the first-line therapy;...

  • Treatment and prevention of hypertension: Where have we been and where are we going? Luft, Friedrich C. // Kidney International Supplement;Aug1995, Issue 50, pS-14 

    Explores the modality of treatment and prevention of hypertension. Identification of genes associated with blood pressure regulation and the development of hypertension; Application of diuretics and beta blockers; Influence of environmental factors on blood pressure.

  • High blood pressure: The uncontrolled epidemic.  // Consumer Reports on Health;Oct2002, Vol. 14 Issue 10, p6 

    Part II. Focuses on the treatment and prevention of high-blood pressure. Accuracy in the prediction of hypertensive complications through systolic pressure; Modification of life style to prevent abnormal blood flow; Effectiveness of diuretics and beta-blockers in lowering hypertension.

  • Secondary hypertension.  // Mayo Clinic Health Letter;Aug2004, Vol. 22 Issue 8, p4 

    Discusses information about secondary hypertension. Kinds of hypertension; Causes of secondary hypertension; Pathophysiology of secondary hypertension; Treatment options.

  • Amlodipine/benazepril combination lowered CVD morbidity, mortality by 20%.  // Cardiology Today;May2008, Vol. 11 Issue 5, p34 

    The article discusses research being done on the effectiveness of the combination therapy of amlodipine and benazepril in single-tablet form for the treatment of high-risk patients with hypertension. It references a study by Kenneth A. Jamerson and colleagues, presented at the 2008 American...

  • A New Preparation of Nifedipine for Sublingual Application in Hypertensive Urgencies. Kürkciyan, Istepan; Sterz, Fritz; Roden, Michael; Heinz, Gottfried; Hirschl, Michael M.; Müllner, Marcus; Laggner, Anton Norbert // Angiology;Jul1994, Vol. 45 Issue 7, p629 

    A new preparation of nifedipine for sublingual application in hypertensive urgencies was investigated in a prospective study. Patients admitted to the Emergency Department with a persistent elevation of systolic blood pressure (SBP) greater than 190 mm Hg and/or a diastolic blood pressure (DBP)...

  • Accurate Dry Weight Assessment: Reducing the Incidence of Hypertension and Cardiac Disease in Patients on Hemodialysis.  // Nephrology Nursing Journal;Nov/Dec2004, Vol. 31 Issue 6, p637 

    Presents a quiz on hypertension control in patients on hemodialysis. Cause of hypertension in patients with kidney disease; Factors affecting the volume of fluid loss a patient can accommodate during hemodialysis; Effect of fluid removal during ultrafiltration.

  • Pediatric blood pressure guidelines get an update.  // Drug Topics;6/7/2004, Vol. 148 Issue 11, p8 

    This article reports that the National High Blood Pressure Education Program Working Group has revised its guidelines regarding the treatment of hypertension in children and adolescents. This fourth report, which updates the group's 1996 guidelines, states that pharmacological therapy for...

  • JNC 7 one year later: Experts confirm, challenge its findings. Alexander, Walter // Drug Topics;7/26/2004, Vol. 148 Issue 14, p17 

    This article reports that recommendations of the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) were both supported and questioned in separate presentations at the American Society of Hypertension's 19th Annual...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics