TITLE

INTERSTITIAL NEPHRITIS REVERSIBILITY OF OSMOTIC NEPHROTIC CHANGES DUE TO MANNITOL PROVED BY RENAL BIOPSY

AUTHOR(S)
Lampe II, William T.
PUB. DATE
May 1965
SOURCE
Angiology;May1965, Vol. 16 Issue 5, p281
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
An unusual ease of acute interstitial nephritis associated with mastoiditis is presented. Anuria secondary to hyponatremia supervened necessitating the use of mannitol which was ineffective. Hypertonic (3%) sodium chloride resulted in immediate sustained diuresis. Antibiotic therapy eliminated the mastoid infection and complete recovery of renal function occurred in 3 months. Reversability of the histologic changes of osmotic nephrosis in the proximal renal tubule was demonstrated for the first time in humans. Also improvement in the interstitial infiltrate was noted on follow up biopsy.
ACCESSION #
16358552

 

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