TITLE

THE ONSET AND DURATION OF ACTION OF CLONITRATE AS MEASURED BY THE BALLISTOCARDIOGRAPHIC RESPONSE

AUTHOR(S)
Krasno, Louis R.; Kidera, George J.
PUB. DATE
May 1965
SOURCE
Angiology;May1965, Vol. 16 Issue 5, p233
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
It has been pointed out that since the ballistocardiogram records the combined hemodynamic response of the force of the heart and peripheral vascular resistance, it is particularly suitable for measuring the response of an agent which acts on both the myocardium and the peripheral blood vessels. This type of measurement is also significant in view of the fact that the efficacy of agents for angina pectoris is thought to be due, in part, to decreased peripheral resistance.4 The ballistocardiographic response to 0.6 mg clonitrate administered sublingually indicates that this agent has an onset of action within 3 minutes and that this activity is sustained for at least a 4-hour period. More importantly this longer duration of effect is also noted when the drug is used therapeutically for the treatment and prophylaxis of angina pectoris.5,7 We have observed in several of our patients that drug requirements were halved or less when they were switched from nitroglycerin to clonitrate. The dual characteristics of rapid onset of action and sustained response should make clonitrate a particularly useful agent in the control of angina pectoris.
ACCESSION #
16358454

 

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