Davis, James W.
July 1973
Angiology;Jul/Aug1973, Vol. 24 Issue 7, p391
Academic Journal
Platelet aggregation was induced by stirring citrated platelet-rich plasma (PRP) with 1.7μM adenosine diphosphate (ADP) at 37° C. Light transmission, which increased with aggregation and decreased with disaggregation, was continuously recorded. Disaggregation, measured as the decrement of light transmission found three min after maximum transmission occurred, was expressed as a percentage of the maximum increment observed after addition of ADF. It was classified as type I (50% or more), II (30–49%), III (10–29%) or IV (<10) The disaggregation types of 227 men under 56 years of age were analyzed. One hundred twenty-four had no known occlusive arterial disease or family history of myocardial infarct before the age of 60. Within this control group the rate of platelet disaggregation appeared to be independent of both age and associated noncardiovascular disease. The disaggregation types of the controls were I (48%), II (16%), III (19%) and IV (16%). Sixty-eight had occlusive arterial diseases with the coronaries involved in 59. Their types were I (27%), II (13%), III (16%) and IV (44%). Type IV was significantly more common and type I significantly less common in the PRP of men with occlusive arterial diseases. Type IV disaggregation occurred with the same frequency in the PRP of patients with occlusive arterial diseases regardless of whether or not an infarction had occurred within two months prior to testing disaggregation types. The frequencies of the disaggregation types of 35 men with a family history of myocardial infarct before the age of 60 were not significantly different from the controls. This work was done in part during the tenure of a Clinical Investigator award from the Veterans Administration. The technical assistance of Mrs. Phyllis E. Phillips is gratefully acknowledged.


Related Articles

  • The determination of the 99th centile level for troponin assays in an Australian reference population. Tate, Jillian R.; Ferguson, Wendy; Bais, Renze; Kostner, Karam; Marwick, Thomas; Carter, Andrew // Annals of Clinical Biochemistry;May2008, Vol. 45 Issue 3, p275 

    Background: Current guidelines for the diagnosis and risk assessment of patients presenting with myocardial infarction recommend a single decision cut-off point for cardiac troponin (cTn) based on the 99th centile of a reference population. The 99th centile level for eight troponin assays was...

  • Make room for aspirin in secondary MI prevention. Pinkowish, Mary Desmond // Patient Care;5/30/1996, Vol. 30 Issue 10, p14 

    Focuses on the use of aspirin in aftercare of elderly patients with myocardial infarction. Positive effects of aspirin on mortality.

  • Antiplatelet Therapy in Peripheral Arterial Disease. Aronow, Wilbert S. // Current Drug Targets - Cardiovascular & Haematological Disorders;Sep2004, Vol. 4 Issue 3, p265 

    Antiplatelet therapy significantly reduces the incidence of vascular death, nonfatal myocardial infarction, and nonfatal stroke in patients with peripheral arterial disease (PAD) and intermittent claudication, in patients undergoing peripheral grafting, in patients undergoing peripheral...

  • Clopidogrel cost effective for prevention of vascular events?  // PharmacoEconomics & Outcomes News;8/14/2004, Issue 459, p9 

    Discusses research being done on the costs of clopidogrel treatment for secondary prevention of vascular events among patients with peripheral arterial disease, a stroke, or either of these in combination with a prior myocardial infarction. Reference to a study by M. D. Schleinitz, et al...

  • PLASMA FIBRINOGEN AND SERUM ALDOLASE IN ACUTE MYOCARDIAL INFARCTION. Losner, Samuel; Volk, Bruno W. // Angiology;Oct1956, Vol. 7 Issue 5, p454 

    Focuses on the study determining the factors causing the rise of the concentration of plasma fibrinogen in the body. Effects of myocardial infarction on the health several individuals; Increase on the risks of death; Description on the physical condition of various patients.

  • Combining PPI and aspirin increases CVD event risk.  // Pulse;6/8/2011, Vol. 71 Issue 21, p9 

    The article reports on the result of the study which suggests that prescribing proton-pump inhibitors to myocardial infarction patients on aspirin can increase their risk of cardiovascular events.

  • Primary or rescue PCI?  // Heart;Jun2008, Vol. 94 Issue 6, p819 

    The article presents a study on the primary percutaneous coronary intervention (PCI) as a treatment for ST elevation myocardial infarction (STEMI). The study used networks of non-PCI centers as spokes and PCI centers as hubs in Poland, Italy, and France. STEMI patients were referred to hubs and...

  • ISIS-2: 10 year survival among patients with suspected acute myocardial infarction in randomised... Baigent, Colin; Collins, Rory; Appleby, Paul; Parish, Sarah; Sleight, Peter; Peto, Richard // BMJ: British Medical Journal (International Edition);05/02/98, Vol. 316 Issue 7141, p1337 

    Presents a study which looks at the effects of intravenous streptokinase and oral aspirin, on survival in patients with suspected acute myocardial infarction. Detailed information on patients and methodologies used in the study; Results of the study; Discussion on the study.

  • Low Incidence of Myocardial Infarction Following Femoral-Popliteal Bypass. Rubio, Pedro A.; Farrell, Edward M.; Guinn, Gene A. // Vascular Surgery;Sep/Oct1979, Vol. 13 Issue 5, p322 

    Ninety-five consecutive male patients had a total of 114 femoral-popliteal bypasses in 5-year period. A clinical diagnosis of coronary artery disease was made in 24 of the patients (25.3%). None of the patients with or without coronary artery disease developed postoperative myocardial...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics