TITLE

DEFECTIVE PLATELET DISAGGREGATION ASSOCIATED WITH OCCLUSIVE ARTERIAL DISEASES

AUTHOR(S)
Davis, James W.
PUB. DATE
July 1973
SOURCE
Angiology;Jul/Aug1973, Vol. 24 Issue 7, p391
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Platelet aggregation was induced by stirring citrated platelet-rich plasma (PRP) with 1.7μM adenosine diphosphate (ADP) at 37° C. Light transmission, which increased with aggregation and decreased with disaggregation, was continuously recorded. Disaggregation, measured as the decrement of light transmission found three min after maximum transmission occurred, was expressed as a percentage of the maximum increment observed after addition of ADF. It was classified as type I (50% or more), II (30–49%), III (10–29%) or IV (<10) The disaggregation types of 227 men under 56 years of age were analyzed. One hundred twenty-four had no known occlusive arterial disease or family history of myocardial infarct before the age of 60. Within this control group the rate of platelet disaggregation appeared to be independent of both age and associated noncardiovascular disease. The disaggregation types of the controls were I (48%), II (16%), III (19%) and IV (16%). Sixty-eight had occlusive arterial diseases with the coronaries involved in 59. Their types were I (27%), II (13%), III (16%) and IV (44%). Type IV was significantly more common and type I significantly less common in the PRP of men with occlusive arterial diseases. Type IV disaggregation occurred with the same frequency in the PRP of patients with occlusive arterial diseases regardless of whether or not an infarction had occurred within two months prior to testing disaggregation types. The frequencies of the disaggregation types of 35 men with a family history of myocardial infarct before the age of 60 were not significantly different from the controls. This work was done in part during the tenure of a Clinical Investigator award from the Veterans Administration. The technical assistance of Mrs. Phyllis E. Phillips is gratefully acknowledged.
ACCESSION #
16358344

 

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