TITLE

PHYSIOLOGIC MEASUREMENT OF INTRAHEPATIC SHUNTED BLOOD FLOW BY METHOD OF CONTINUOUS INFUSION OF D-GALACTOSE-1-C14

AUTHOR(S)
Nakamura, Shozo; Sasaki, Ko; Takezawa, Yoshiaki; Yoshida, Gen; Sato, Takashi
PUB. DATE
July 1974
SOURCE
Angiology;Jul/Aug1974, Vol. 25 Issue 7, p484
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
An improved method is presented for the determination of the intrahepatic shunted blood flow. D-Galactose-1-C14 and T-1824 dye were continuously infused at a constant rate into the pulmonary artery. Per cent intrahepatic shunt was calculated from the radioactivities and dye concentrations of the arterial and the hepatic venous blood. Per cent intrahepatic shunt of 4 controls and 2 patients with acute viral hepatitis was 8–18. Twelve patients with chronic hepatitis showed 6–29 per cent of intrahepatic shunt with an average of 20 per cent, and 16 patients with hepatic cirrhosis showed 23–60 per cent of shunt with an average of 35 per cent. Thus, per cent intrahepatic shunt increased slightly in chronic hepatitis and markedly in hepatic cirrhosis. The range of overlap of per cent intrahepatic shunt between hepatic cirrhosis and chronic hepatitis was narrower by the present continuous infusion method than by the previous rapid injection method. There were statistically significant correlations between the per cent intrahepatic shunt and the per cent of interstitial tissue and between the per cent intrahepatic shunt and the wedged hepatic venous pressure.
ACCESSION #
16358115

 

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