Fitzgerald, D. E.; Frisch, E. P.
July 1974
Angiology;Jul/Aug1974, Vol. 25 Issue 7, p444
Academic Journal
The proteolytic enzyme brinase administered intravenously has been found to relieve 22 out of 34 chronically obstructed leg arteries in a group of 16 patients. The treatment resulted in relief of symptoms and an increase in systolic blood pressure in the affected limbs. Ultrasound techniques were used for observing and classifying the arterial circulation and the response to treatment.


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