Voudoukis, Ignatios J.
September 1973
Angiology;Sep1973, Vol. 24 Issue 8, p472
Academic Journal
The systolic, diastolic and pulse pressure cold-pressor response was determined, following baseline blood pressure measurements in 641 consecutive patients of a predominantly hypertensive population. The series consisted of four groups having: A) Normotension without arteriosclerosis (83 patients), B) Arteriosclerosis without hypertension (66 patients), C) Hypertension without arteriosclerosis (93 patients) and D) Hypertension plus arteriosclerosis (399 patients). The mean values � SD in mm Hg of the cold-pressor response in the four groups were respectively for: Systolic cold-pressor response 25 � 13, 44 � 15, 29 � 14 and 52 � 17; diastolic cold-pressor response 25 � 10, 25 � 10, 26 � 11 and 29 � 12; pulse pressure cold-pressor response 0 � 11, 19 � 9, 3 � 11 and 23 � 12. The study was computerized and the data was subjected to analysis of covariance for the four groups after adjusting with age. Comparison of A and B showed significant difference in systolic and pulse pressure cold-pressor response and no significant difference in diastolic cold-pressor response. Comparison of A and C showed no significant difference in systolic, diastolic or pulse pressure cold-pressor response. Comparison of C and D showed significant difference in systolic, diastolic and pulse pressure cold-pressor response. During the six-year period of the study 20 of the 641 patients died. All of the deceased�except one�were hyperreactors to cold stimulus and all were found to have atherosclerosis, arteriolosclerosis or both, either clinically or at autopsy. In 16 of the 20 deceased patients, the probable cause of death was either coronary heart disease or cerebrovascular disease. The results indicate that 1. The cold-pressor response in normotensive and hypertensive individuals is similar. 2. Arteriosclerosis alone or superimposed in hypertension is associated with exaggerated systolic and pulse pressure cold-pressor response. 3. When both arteriosclerosis and hypertension coexist there is also exaggeration in diastolic cold-pressor response. In conclusion, the cold-pressor test may be used as a screening test for arteriosclerosis in both normotensive and hypertensive populations.


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