TITLE

THE EFFECT OF SODIUM 2-PHENYLBUTYRATE IN EXPERIMENTAL ATHEROSCLEROSIS

AUTHOR(S)
Kritchevsky, David; Moyer, Arden W.; Tesar, Walter C.; McCandless, Robert F. J.; Logan, John B.; Brown, Raymond A.; Englert, Mary
PUB. DATE
April 1956
SOURCE
Angiology;Apr1956, Vol. 7 Issue 2, p156
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
1. Sodium 2-phenylbutyrate, in the form of the pure salt and of compounded pills, was assayed for its hypocholesterolemic properties and for its effect on atherosclerosis in cholesterol-fed rabbits. 2. Serum cholesterol levels were significantly lowered in the animals on the pure salt (P < .01) and the pills (P = .01). The atheromata in the thoracic aorta and aortic arch were somewhat lower but not significantly so. 3. Hemorrhagic kidneys were seen in 6 of 19 rabbits on the pills and 3 of 17 on the salt.
ACCESSION #
16357957

 

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