BLOOD VESSEL WALL CHARACTERISTICS IN EXPERIMENTAL HYPERTENSION
Angiology;Dec1974, Vol. 25 Issue 11, p752
A comparative study of the vascular reactivity and elasticity of blood vessels obtained from normal and cadmium-hypertensive rabbits and dogs was made utilizing in vitro techniques. It was found that the normal rabbit thoracic aorta was considerably more responsive to angiotensin and norepinephrine in comparison with the normal dog carotid artery. The vascular reactivity of hypertensive rabbit aorta was significantly lower with angiotensin. The hypertensive dog carotid artery tended to be less responsive with angiotensin, norepinephrine and serotonin in comparison with the normal carotid artery. Stress-strain characteristic studies revealed that the hypertensive rabbit aorta and the hypertensive dog carotid artery developed significantly lower passive modulus of elasticity in comparison with the normal blood vessels upon step-wise increases in passive strain applied from 0-80% and 0-140% respectively. The addition of angiotensin and norepinephrine in the muscle chamber shifted the regression lines of modulus of passive elasticity to the left in the case of hypertensive rabbit aorta but not in hypertensive dog carotid artery. Although the wall thickness of hypertensive rabbit aorta was unchanged, the hypertensive dog carotid artery wall thickness was significantly greater than that of normal carotid artery. Renal vascular reactivity and vascular morphology was studied utilizing in vivo magnification selective renal arteriography. There were significant morphological changes in the cortical and distal interlobar arteries, and decreased vasconstrictive responsiveness with intra-renal artery bolus injections of angiotensin and norepinephrine following the intraperitoneal injections of cadmium acetate in our chronic study dogs. These changes were associated with a very significant sequestration of cadmium into the kidney and abnormalities in renin-angiotensin system. It is probable that the total amount of cadmium administered, the duration of hypertension and the lack of atherosclerotic changes in the cardiovascular system and other factors, were responsible for the observed changes in the blood vessel wall characteristics. It is also possible tbat in chronic cadmium hypertension with accompanying atherosclerotic changes in the target organs, one would find the more conventional changes of increased modulus of passive elasticity in the blood vessels of hypertensive animals. Since no such data are available, long-term pathophysiological studies should be undertaken in this form of hypertension.
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The increase in cross-sectional area within an arterial bifurcation is shown to be much larger than that predicted by the conventional area ratio ï¿½. Modified area ratios which better describe this increase are presented and their values are assessed both from theoretical considerations and...
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- CLINICAL STUDIES OF NORPACE (Part V). Cook, William R. // Angiology;Jan1975 Part 2, Vol. 26, p140
Examines the effect of Norpace therapy among patients with cardiovascular related diseases. Medical history of the patients; Development of atrial fibrillation during the placebo period in patients with cardiomyopathy; Implications of the therapy for patients with arteriosclerotic heart disease.
- CLINICAL STUDIES OF NORPACE (Part IV). Nisbet, Thomas // Angiology;Jan1975 Part 2, Vol. 26, p138
Examines the effect of Norpace therapy among patients with cardiovascular related diseases. Medical history of the patients; Percentage of reduction in extrasystolic activity; Criteria of the lowest placebo incidence versus the highest Norpace incidence.
- CLINICAL STUDIES OF NORPACE (Part VI). Pugh, David M. // Angiology;Jan1975 Part 2, Vol. 26, p142
Examines the effect of Norpace therapy among patients with cardiovascular related diseases. Medical history of the patients; Implications of the therapy for patients with ventricular tachycardia; Correlation between symptomatology and the presence of ventricular arrhythmias.
- CLINICAL STUDIES OF NORPACE (Part VII). Berman, Reuben // Angiology;Jan1975 Part 2, Vol. 26, p143
Examines the effect of Norpace therapy among patients with cardiovascular related diseases. Medical history of the patients; Implications of the therapy for patients with hypertension or coronary disease; Indication of supraventricular tachycardia on placebo before and after Norpace.
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