TITLE

BLOOD VESSEL WALL CHARACTERISTICS IN EXPERIMENTAL HYPERTENSION

AUTHOR(S)
Thind, Gurdarshan S.
PUB. DATE
December 1974
SOURCE
Angiology;Dec1974, Vol. 25 Issue 11, p752
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A comparative study of the vascular reactivity and elasticity of blood vessels obtained from normal and cadmium-hypertensive rabbits and dogs was made utilizing in vitro techniques. It was found that the normal rabbit thoracic aorta was considerably more responsive to angiotensin and norepinephrine in comparison with the normal dog carotid artery. The vascular reactivity of hypertensive rabbit aorta was significantly lower with angiotensin. The hypertensive dog carotid artery tended to be less responsive with angiotensin, norepinephrine and serotonin in comparison with the normal carotid artery. Stress-strain characteristic studies revealed that the hypertensive rabbit aorta and the hypertensive dog carotid artery developed significantly lower passive modulus of elasticity in comparison with the normal blood vessels upon step-wise increases in passive strain applied from 0-80% and 0-140% respectively. The addition of angiotensin and norepinephrine in the muscle chamber shifted the regression lines of modulus of passive elasticity to the left in the case of hypertensive rabbit aorta but not in hypertensive dog carotid artery. Although the wall thickness of hypertensive rabbit aorta was unchanged, the hypertensive dog carotid artery wall thickness was significantly greater than that of normal carotid artery. Renal vascular reactivity and vascular morphology was studied utilizing in vivo magnification selective renal arteriography. There were significant morphological changes in the cortical and distal interlobar arteries, and decreased vasconstrictive responsiveness with intra-renal artery bolus injections of angiotensin and norepinephrine following the intraperitoneal injections of cadmium acetate in our chronic study dogs. These changes were associated with a very significant sequestration of cadmium into the kidney and abnormalities in renin-angiotensin system. It is probable that the total amount of cadmium administered, the duration of hypertension and the lack of atherosclerotic changes in the cardiovascular system and other factors, were responsible for the observed changes in the blood vessel wall characteristics. It is also possible tbat in chronic cadmium hypertension with accompanying atherosclerotic changes in the target organs, one would find the more conventional changes of increased modulus of passive elasticity in the blood vessels of hypertensive animals. Since no such data are available, long-term pathophysiological studies should be undertaken in this form of hypertension.
ACCESSION #
16357918

 

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