TITLE

MYOCARDIAL AND PLASMA LACTATE CHANGES IN ARTERIOSCLEROTIC AND NON-ARTERIOSCLEROTIC RATS DURING ISOPROTERENOL-INDUCED INFARCTION

AUTHOR(S)
Wexler, Bernard C.; Lutmer, Robert F.
PUB. DATE
January 1972
SOURCE
Angiology;Jan1972, Vol. 23 Issue 1, p36
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Myocardial infarction was induced in non-arteriosclerotic and arteriosclerotic, male and female, Sprague-Dawley rats, by giving two. separate, relatively large doses of isoproterenol. Myocardial and blood lactate levels were measured at selected time intervals after each of the two injections spaced 24 hours apart. Both the arteriosclerotic and nonartcriosclerotic animals responded similarly manifesting a prompt rise in blood and cardiac lactate production after the first injection. There was little or no increased lactate production on Day 2 following the second injection when overt myocardial necrosis was becoming established. These findings are interpreted to indicate that the myocardium of these animals was able to adapt to the stress of the first injection of isoproterenol, i.e., increased lactate production indicative of compensatory anaerobic metabolism. but they were unable to adapt to the shock and myocardial necrosis-inducing effects of the second dose of isoprotorenol. The pre-existing condition of coronary arteriosclerosis in the arteriosclerotic animals did not compromise their ability to survive and was not reflected in lactic acid increase. The blood lactic acid level is considered to be a good prognostic index of myocardial ischemia or anoxia.
ACCESSION #
16357619

 

Related Articles

  • Effect of glialin on cardiac ventricular arrhythmias and myocardial conduction system in dogs. R. Khisamutdinova; F. Zarudii; S. Gabdrakhmanova; N. Makara; N. Baschenko; V. Nazarov // Bulletin of Experimental Biology & Medicine;Mar2007, Vol. 143 Issue 3, p353 

    Abstract  Intravenous glialin in a dose of 7 mg/kg suppressed the number of ectopic contractions caused by double ligature of the left coronary artery by the method of Harris and almost 2-fold prolonged animal life-span in comparison with the control. The maximum antiarrhythmic effect of...

  • The predictive value of cumulative lactate dehydrogenase release within the first 72 h of acute myocardial infarction in patients treated with primary angioplasty. Elsman, Peter; Zijlstra, Felix; Miedema, Kor; Hoorntje, Jan C A; Dikkeschei, Lambert D; Slingerland, Robbert J; Reiffers, Stoffer; de Boer, Menko-Jan; Suryapranata, Harry // Annals of Clinical Biochemistry;Mar2004, Vol. 41 Issue 2, p142 

    Background: In patients with acute myocardial infarction, estimation of infarct size by cumulative lactate dehydrogenase release at 72 h (LDHQ72) is a simple and widely used method. Our objective was to study the value of estimating infarct size, by the cumulative release of LDH over 72, 60, 48...

  • Ratiometric imaging of calcium during ischemia-reperfusion injury in isolated mouse hearts using Fura-2. Venkataraman, Raghav; Holcomb, Mark R.; Harder, Rene; Knollmann, Bj�rn C.; Baudenbacher, Franz // BioMedical Engineering OnLine;2012, Vol. 11 Issue 1, p39 

    Background: We present an easily implementable method for measuring Fura-2 fluorescence from isolated mouse hearts using a commercially available switching light source and CCD camera. After calibration, it provides a good estimate of intracellular [Ca2+] with both high spatial and temporal...

  • Final Myocardial Blush Grade Predicts Troponin I Elevation in Unstable Angina Patients Undergoing Percutaneous Intervention. Prasan, Ananth M.; Flood, Christopher; Pitney, Mark R.; Walsh, Warren; Jepson, Nigel S. // Heart, Lung & Circulation;Oct2006, Vol. 15 Issue 5, p291 

    Background: Improved myocardial blush grade is associated with better MACE outcomes in acute myocardial infarction patients but there are no data on myocardial blush grade (MBG) assessment in unstable angina (UA) patients treated with coronary intervention. We sought to evaluate the use of...

  • Percutaneous Closure of Left Ventricular Free Wall Rupture with Associated False Aneurysm to Prevent Cardioembolic Stroke. Harrison, Wil; Ruygrok, Peter N.; Greaves, Sally; Wijesinghe, Namal; Charleson, Hamish; Wade, Clyde; Devlin, Gerard // Heart, Lung & Circulation;Jun2008, Vol. 17 Issue 3, p250 

    Left ventricular (LV) false aneurysm is an uncommon complication of myocardial infarction. Conventional treatment mandates surgical repair but is associated with significant perioperative risk. We present a case of successful percutaneous closure of a LV false aneurysm in a patient at high...

  • Cardiac Rupture in Embolic Myocardial Infarction after Implantation of a Valved Aortic Conduit. Lamm, G.; Auer, J.; Maurer, E.; Hartl, P.; Eber, B. // Heart, Lung & Circulation;Jun2008, Vol. 17 Issue 3, p256 

    We report a case of an apical myocardial infarction complicated by left ventricular wall rupture due to coronary artery embolism four years after surgery of an acute type A dissection of an aortic aneurysm with implantation of a valved aortic conduit.

  • Aalen Additive Hazards Change-Point Model. Torben Martinussen; Thomas H. Scheike // Biometrika;Dec2007, Vol. 94 Issue 4, p861 

    We study a test comparing the full Aalen additive hazards model and the change-point model, and suggest how to estimate the parameters of the change-point model. We also study a test for no change-point effect. Both tests are provided with large sample properties and a resampling method is...

  • Postconditioning: Reduction of reperfusion-induced injury. Zhao, Zhi-Qing; Vinten-Johansen, Jakob // Cardiovascular Research;May2006, Vol. 70 Issue 2, p200 

    Abstract: Reperfusion has the potential to introduce additional injury that is not evident at the end of ischaemia per se, i.e. reperfusion injury. Reperfusion injury is expressed as endothelial and microvascular dysfunction, impaired blood flow, metabolic dysfunction, cellular necrosis, and...

  • The end-effectors of preconditioning protection against myocardial cell death secondary to ischemia�reperfusion. Garcia-Dorado, David; Rodriguez-Sinovas, Antonio; Ruiz-Meana, Marisol; Inserte, Javier; Agull�, Luis; Cabestrero, Alberto // Cardiovascular Research;May2006, Vol. 70 Issue 2, p274 

    Abstract: Our understanding of the end-effectors involved in preconditioning protection is still very limited. This is partially due to an incomplete knowledge of the mechanisms responsible for acute sarcolemmal rupture and cell death during the first minutes of reperfusion, including the...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics