TITLE

MYOCARDIAL AND PLASMA LACTATE CHANGES IN ARTERIOSCLEROTIC AND NON-ARTERIOSCLEROTIC RATS DURING ISOPROTERENOL-INDUCED INFARCTION

AUTHOR(S)
Wexler, Bernard C.; Lutmer, Robert F.
PUB. DATE
January 1972
SOURCE
Angiology;Jan1972, Vol. 23 Issue 1, p36
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Myocardial infarction was induced in non-arteriosclerotic and arteriosclerotic, male and female, Sprague-Dawley rats, by giving two. separate, relatively large doses of isoproterenol. Myocardial and blood lactate levels were measured at selected time intervals after each of the two injections spaced 24 hours apart. Both the arteriosclerotic and nonartcriosclerotic animals responded similarly manifesting a prompt rise in blood and cardiac lactate production after the first injection. There was little or no increased lactate production on Day 2 following the second injection when overt myocardial necrosis was becoming established. These findings are interpreted to indicate that the myocardium of these animals was able to adapt to the stress of the first injection of isoproterenol, i.e., increased lactate production indicative of compensatory anaerobic metabolism. but they were unable to adapt to the shock and myocardial necrosis-inducing effects of the second dose of isoprotorenol. The pre-existing condition of coronary arteriosclerosis in the arteriosclerotic animals did not compromise their ability to survive and was not reflected in lactic acid increase. The blood lactic acid level is considered to be a good prognostic index of myocardial ischemia or anoxia.
ACCESSION #
16357619

 

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