Charman, Robert C.; Matthews, Louis B.; Braeuler, Charlotte
January 1972
Angiology;Jan1972, Vol. 23 Issue 1, p29
Academic Journal
One hundred and sixty patients were treated with nicotinic acid for hypercholesterolemia and followed for periods up to twelve years. The mean percentage decrease of serum cholesterol was 26%. The majority of dropouts occurred during the early phases of treatment. The major side effects demonstrated were gastrointestinal symptoms including a 5.6% incidence of peptic ulcer. No evidence of serious irreversible side effects was demonstrated in a total 868 patient- years of treatment. Although side effects are a definite deterrent to some users of nicotinic acid, the drug is still of major importance in the therapy of hypercholesterolemia.


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