TITLE

THE ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN THE INITIATION OF RENOVASCULAR HYPERTENSION

AUTHOR(S)
Barger, A. C.
PUB. DATE
June 1976
SOURCE
Angiology;Jun1976, Vol. 27 Issue 6, p341
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Studies the role of the renin-angiotensin system in the initiation of renovascular hypertension in unilaterally nephrectomized dogs with renal artery constriction. Administration of the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro to the nephrectomized dogs to determine whether the rise in blood pressure and systemic plasma renin activity were casually related; Prevention of rise in systemic blood pressure after renal artery constriction by blockade of conversion of angiotensin I to angiotensin II by the nonapeptide; Correlation between increase in body weight and rise in blood pressure in the animals following renal artery constriction.
ACCESSION #
16357206

 

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