Kones, Richard J.; Dombeck, David H.; Phillips, John H.
October 1972
Angiology;Oct1972, Vol. 23 Issue 9, p525
Academic Journal
Twelve patients with cardiogenic shock were given a continuous intravenous infusion of glucagon at a rate of 3 mg/hour. Four patients with an acute myocardial infarction occurring as their first clinical manifestation of heart disease survived. All eight who died had heart diseases of long duration prior to the onset of cardiogenic shock. As would be expected, increased urine output, stable restored blood pressures, and decreased central venous pressures indicated a more favorable prognosis. Hypokalemia, hypocalcemia, and hyperglycemia were consequences of extracardiac metabolic actions of glucagon. Suppression of premature ventricular complexes reflected an antiarrhythmic property of glucagon. More intense and frequent chest pain (two patients) and depressed ST segments on ECG (one patient) during glucagon therapy was noted. Since glucagon is considered a secondary coronary vasodilator, these observations suggest further experience is necessary. Glucagon may be of greater benefit in cardiogenic shock when clinical heart diseases of long duration did not precede the onset of the shock syndrome. More investigation with this agent appears warranted.


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