TITLE

EXPERIENCE WITH THE USE OF AN ALDOSTERONE ANTAGONIST IN SELECTED HYPERTENSIVE PATIENTS

AUTHOR(S)
Kert, Morley J.; Tarr, Lester W.; Frank, Stanley; Gold, Ernest; Okun, Ronald; Maxwell, Morton
PUB. DATE
November 1972
SOURCE
Angiology;Nov1972, Vol. 23 Issue 10, p617
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Eleven patients selected from a hypertension clinic were given spironolactone (300 mg/day) for four weeks. Six of the patients had spontaneous hypokalemia prior to the spironolactone therapy and five were control patients. Spironolactone caused significant reduction in blood pressure particularly in the standing position in all patients but supine reductions in blood pressure were only significant in the hypokalemic group. Patients with impaired renal function developed further decreases in renal function and serum carbon dioxide and significant hyperkalemia following spironolactone therapy. All patients who had 24 hour urine excretion of aldosterone measured developed significant elevations of urine aldosterone excretion following the spironolactone therapy except the two patients who had pre-treatment elevations of urine aldosterone excretion. The significance of these changes were discussed.
ACCESSION #
16357112

 

Related Articles

  • Spironolactone may save the day with resistant hypertension. Kuritzky, Louis // Internal Medicine Alert;2/28/2011 Supplement, p32 

    The article reports on a study conducted by M. Engbaek and colleagues which discovers the effectiveness of spironolactone (SPIR), an aldosterone antagonist with modest diuretic activity, in decreasing blood pressure independent of aldosterone status.

  • Aldosterone Receptor Antagonists for Hypertension: What Do They Offer? Liew, Danny; Krum, Henry // Drugs;2003, Vol. 63 Issue 19, p1963 

    Aldosterone is an important and independent target for therapeutic intervention in hypertension and hypertension-related diseases. Its actions, once thought to be limited to the distal convoluted tubule of the kidney, are now recognised to be wide-ranging, including interactions with...

  • High ambient temperatures and hypokalaemia. Jones, Katie L.; Zouwail, Soha // Annals of Clinical Biochemistry;Jan2014, Vol. 51 Issue 1, p114 

    A letter to the editor is presented about seasonal pseudohypokalaemia.

  • Aldosterone Antagonism Fails to Attenuate Age-Associated Left Ventricular Fibrosis. Hyun Seok Hwang; Cirrincione, Georgina; Thomas, D. Paul; McCormick, Richard J.; Boluyt, Marvin O. // Journals of Gerontology Series A: Biological Sciences & Medical ;Apr2007, Vol. 62A Issue 4, p382 

    Collagen accumulates disproportionately in cardiac remodeling induced by hypertension and associated with advancing age. Spironolactone (Spiro), an aldosterone antagonist, attenuates the accumulation of collagen induced by hypertension. It was hypothesized that Spiro would attenuate the...

  • Combination Therapy as First-Line Treatment for Hypertension. Crawford, Michael H. // American Journal of Cardiovascular Drugs;2009, Vol. 9 Issue 1, p1 

    Systemic hypertension is a long-term risk factor for the development of atherosclerotic vascular disease and when uncontrolled is a short-term trigger of acute vascular events such as acute coronary syndromes and stroke. Thus, rapid reduction in BP is desirable. Patients at high risk for...

  • Chronic hypokalaemia in a hypertensive patient. Elitok, Saban; Luft, Friedrich C. // Clinical Kidney Journal;Jun2012, Vol. 5 Issue 3, p223 

    Hypokalaemia in hypertensive patients is a ‘red flag’ bringing to mind various classic secondary and genetic causes related to both hypokalaemia and hypertension. We encountered a patient who had an unusual cause for his disturbance that, to our knowledge, has not been described in...

  • Acid-Base Balance-Electrolyte Quiz - Case 35. Filippatos, T.; Elisaf, M. // Archives of Hellenic Medicine / Arheia Ellenikes Iatrikes;2013, Vol. 30 Issue 5, p630 

    A quiz concerning the diagnosis of a 22-year-old woman with persistent hypokalemia is presented.

  • Therapy of Fluid and Electrolyte Disorders. Lindeman, Robert D.; Papper, Solomon // Annals of Internal Medicine;Jan75, Vol. 82 Issue 1, p64 

    Focuses on the management of only selected aspects of fluid and electrolyte disorders. Sodium and water imbalance; Hypokalemia; Hyperkalemia; Hypocalcemia.

  • When the patient has hypokalemia. Toto, Kathleen H. // RN;Mar87, Vol. 50 Issue 3, p38 

    Presents guidelines for nurses on the treatment of patients with hypokalemia. Signs and symptoms of hypokalemia; Patients at risk for hypokalemia; Special precautions when restoring potassium by mouth and infusion. INSET: Balancing intracellular and extracellular potassium.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics