TITLE

INHIBITION OF AGGREGATION OF HUMAN AND RAT PLATELETS BY FIBRINOLYTIC DRUG PHENFORMIN

AUTHOR(S)
Kov�cs, Iren B.; Csalay, L.; G�r�g, P.
PUB. DATE
April 1972
SOURCE
Angiology;Apr1972, Vol. 23 Issue 4, p223
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aggregation of human platelets by ADP, adrenaline and collagen was inhibited by phenformin in citrated plasma. As low as 12.5 �g/ml final concentration of phenformin resulted 50% inhibition of adrenaline induced aggregation of platelets. Platelet aggregation induced by ADP was greatly enhanced by adrenaline in citrated plasma of rat. Applied in low concentration phenformin diminished the adrenaline-induced increased sensitivity of rat platelets to ADP. Phenformin is an oral antidiabetic drug, the effectiveness of which to increase fibrinolytic activity of blood have been established by Fearnley and Chakrabarti (1) and supported by Isacson and Nilsson (2). Besides antidiabetic and fibrinolytic activity Phenformin has a blood cholesterol level lowering effect (3). Phenformin in combination with ethyloestrenol proved to be effective in the treatment of various occlusive vascular diseases (4). In human subjects the drug-combination decreased the adhesiveness of platelets to glass beads but Phenformin alone was without effect (4). We have not found any data concerning the effect of Phenformin on aggregation of platelets of the blood of humans or experimental animals. Because the importance of platelet aggregation and ping formation in hemostasis and thrombosis has been well established, it seemed interest to investigate the effect of Phenformin from this aspect.
ACCESSION #
16355088

 

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