TITLE

DETERMINANTS OF CORONARY FLOW PATTERN

AUTHOR(S)
Moulopoulos, S. D.; Anthopoulos, L. P.; Stamatelopoulos, S. F.
PUB. DATE
January 1973
SOURCE
Angiology;Jan1973, Vol. 24 Issue 1, p29
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The effect of aconitine induced arrhythmia and of bleeding on the coronary flow pattern was studied in open chest dogs. A parallel change of the aortic-left ventricular pressure difference and the coronary arterial flow pattern was observed when the aortic valve was closed. With an open aortic valve, during ejection, the aortic pressure-left ventricular pressure difference became negative, while the coronary flow pattern exhibited a positive systolic wave. The following correlations were observed between the height of the systolic wave (peak systolic coronary arterial flow-PSCAF) and other parameters: a) a direct relationship between peak left ventricular pressure and PSCAF. This relationship was inverse for beats producing the same peak aortic flow, b) an inverse relationship between aortic end diastolic pressure and PSCAF. c) a direct relationship between peak aortic flow and PSCAF, and d) an inverse relationship between peak dP/dt and PSCAF. These correlations are in agreement with the mathematical derivations from a mathematical model of the coronary circulation.
ACCESSION #
16354129

 

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