Effect of Propranolol on Baroreflex Control of Heart Rate in Young Patients with Essential Hypertension

Takata, Shigeo; Ogawa, Jun; Okuwa, Hitoshi; Yagi, Shinji; Iwase, Nobuo; Ikeda, Takayuki; Hattori, Nobu
February 1986
Angiology;Feb1986, Vol. 37 Issue 2, p106
Academic Journal
The effect of propranolol on baroreflex control of heart rate was studied in 12 young patients with essential hypertension and was compared with that of 12 age-matched normotensive subjects. Resting heart rate and cardiac index in patients with essential hypertension were significantly higher than those of control subjects (p < 0.001, p < 0.01, respectively). The reduction of heart rate and cardiac index after propranolol were significantly greater in patents with essential hypertension than in control subjects (p < 0.01, p < 0.05, respectively). In the control state, the baroreflex slope in young patients with essential hypertension was significantly less than that of control subjects (p < 0.01). After propranolol, the baroreflex slope was significantly increased in control subjects (p < 0.01), but remained unchanged in patients with essential hypertension. These results suggest, first that the antihypertensive action of propranolol must be due to a mechanism other than the augmented baroreflex function and, second that increased β-adrenergic activity is not a factor contributing to impaired baroreflex function in young patients with essential hypertension.


Related Articles

  • Recognition of individual heart rate patterns with cepstral vectors. Curcie, David J.; Craelius, William // Biological Cybernetics;1997, Vol. 77 Issue 2, p103 

    Abstract. Heart rate patterns may contain diagnostic as well as forensic information. To test these possibilities, individual heart rate patterns were represented as heart-rate cepstral vectors (HRCVs) computed in 12 dimensions via linear predictive coding (LPC) of brief segments of heart rate....

  • C. Hypertension and Systemic Disease.  // Kidney;Nov/Dec2005, Vol. 14 Issue 6, p274 

    The article presents abstracts of several studies on hypertension and systemic disease. Dissertations that are listed include "Guidelines for the Management of Chronic Kidney Disease in HIV-Infected Patients: Recommendations of the HIV Medicine Association of the Infectious Diseases Society...

  • Reliability of Noninvasive Methods to Measure Cardiac Autonomic Function. Amara, Catherine E.; Wolfe, Larry A. // Canadian Journal of Applied Physiology;Aug98, Vol. 23 Issue 4, p396 

    Analyzes the reliability of noninvasive methods to measure cardiac autonomic function. Use of frequency domain analysis of heart rate variability to assess cardiac autonomic function at rest; Comparison of resting spontaneous baroreflex function on two separate days; Examination of beat-to-beat...

  • Effects of Carvedilol Therapy on Autonomic Function and Baroreflex Sensitivity in Individuals with Newly-Diagnosed Essential Hypertension. Strano, S.; Mazzei, A.; Calcagnini, G.; Ferrucci, A.; Lino, S.; de Pasquale, F.; Massimociavarella, G. // Clinical Drug Investigation;2000, Vol. 19 Issue 1, p63 

    Objective: To investigate the effects of carvedilol therapy on autonomic cardiovascular regulation and baroreflex sensitivity, by short-term spectral analysis of heart rate (R-R) and systolic blood pressure (S-S) variability. Patients and Methods: The trial was conducted in 12 adults (seven men...

  • Inflammation does not influence arterial stiffness and pulse-wave velocity in patients with coronary artery disease. Blann, A D; Kuzniatsova, N; Lip, G Y H // Journal of Human Hypertension;Oct2013, Vol. 27 Issue 10, p629 

    Vascular function is an important pathophysiological factor in cardiovascular disease, and is influenced by many factors, one of the principles being hypertension. Developing evidence suggests that inflammation may be another risk factor. Vascular function and blood pressure haemodynamics can be...

  • Carotid baroreflex responsiveness in normotensive African Americans is attenuated at rest and during dynamic leg exercise. Holwerda, Seth W.; Samels, Mitchel R.; Keller, David M. // Frontiers in Physiology;Mar2013, p1 

    Evidence suggests differences between African Americans (AAs) and Caucasian Americans (CAs) in cardiovascular responsiveness to physiological stressors. This study tested the hypothesis that carotid baroreflex (CBR) control of heart rate (HR) and blood pressure is reduced in AAs compared to CAs...

  • Evaluation of baroreflex control of heart rate in renovascular hypertensive mice. Gava, Agata L.; Vasquez, Elisardo C.; Meyrelles, Silvana S.; Peotta, Veronica A. // Canadian Journal of Physiology & Pharmacology;Aug2007, Vol. 85 Issue 8, p761 

    The objective of the present study was to evaluate the baroreflex and the autonomic control of heart rate (HR) in renovascular hypertensive mice. Experiments were carried out in conscious C57BL/6 (n = 16) mice 28 days after a 2-kidney 1-clip procedure (2K1C mice) or a sham operation (sham mice)....

  • The Effect of Baroreflex Function on Blood Pressure Variability. Xiufang Wei; Xinhui Fang; Lina Ren; Yanyan Meng; Zixin Zhang; Yongquan Wang; Guoxian Qi // International Journal of Clinical Medicine;Sep2013, Vol. 4 Issue 9, p378 

    Objective: The aim of this study was to assess the relationship of blood pressure variability (BPV) and heart rate variability (HRV) to investigate the effect of baroreflex function on blood pressure variability. Methods: This study consisted of 111 subjects, including 32 normotensives and 79...

  • Effects of Celiprolol and Bisoprolol on Blood Pressure, Vascular Stiffness, and Baroreflex Sensitivity. Kazuo Eguchi; Satoshi Hoshide; Kazuomi Kario // American Journal of Hypertension;Jul2015, Vol. 28 Issue 7, p858 

    BACKGROUND We tested the hypothesis that celiprolol and bisoprolol have differential effects on blood pressure (BP), flow-mediated dilation (FMD), and vascular stiffness. METHODS We analyzed 102 hypertensives (mean age: 59 ± 14 years) who were being treated other than beta-blockers. They were...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics