Tissue Damage in Sickle Cell Disease as Assessed by Serum Acid Phosphatase
- Arthropathy in Sickle-Cell Disease . Schumacher, H. Ralph; Andrews, Ronald; McLaughlin, George // Annals of Internal Medicine;Feb73, Vol. 78 Issue 2, p203
Presents a study that described seven patients with sickle-cell disease and symptomatic joint effusions. Result of the use of acid phosphatase; Concern raised in having joint effusions; Speculation on the cause of the effusions; Proposal on the cause of the mechanism for infarction.
- Mechanism of Testosterone Deficiency in the Transgenic Sickle Cell Mouse. Musicki, Biljana; Zhang, Yuxi; Chen, Haolin; Brown, Terry R.; Zirkin, Barry R.; Burnett, Arthur L. // PLoS ONE;May2015, Vol. 10 Issue 5, p1
Testosterone deficiency is associated with sickle cell disease (SCD), but its underlying mechanism is not known. We investigated the possible occurrence and mechanism of testosterone deficiency in a mouse model of human SCD. Transgenic sickle male mice (Sickle) exhibited decreased serum and...
- Pediatric Renal Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions and Clinicopathologic Associations. Altinok, G.; Kattar, M. M.; Mohamed, A.; Poulik, J.; Grignon, D.; Rabah, R. // Pediatric & Developmental Pathology;Mar/Apr2005, Vol. 8 Issue 2, p168
Renal cell carcinomas (RCCs) arc rare in children and studies of their subtypes and clinicopathologic associations arc limited to small series. We identified 8 patients with RCC treated at our institution between 1981 and 2003, reviewed their clinicopathologic features, cytogenetics findings,...
- Cut and Paste: restoring cellular function by gene correction. Liu, Guang-Hui; Sancho-Martinez, Ignacio; Belmonte, Juan Carlos Izpisua // Cell Research;Feb2012, Vol. 22 Issue 2, p283
The article presents research related to the restoration of cellular function by gene correction. It is stated that gene correction technologies may lead to the precise excision of mutant genes responsible for monogenic disease. Recently, many research groups have demonstrated the successful...
- Risk factors for osteonecrosis of the femoral head in patients with sickle cell disease. Akinyoola, A.; Adediran, I.; Asaleye, C.; Bolarinwa, A. // International Orthopaedics;Aug2009, Vol. 33 Issue 4, p923
The mechanisms involved in the pathogenesis of osteonecrosis of the femoral head in sickle cell disease are not fully known. The aim of this study was to identify risk factors for osteonecrosis of the femoral head among sickle cell disease patients. Clinical (frequency of painful crises and...
- Sickle cell disease: old discoveries, new concepts, and future promise. Frenette, Paul S.; Atweh, George F. // Journal of Clinical Investigation;Apr2007, Vol. 117 Issue 4, p850
The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some...
- Mystery of the Crooked Cell. DeRosa, Donald A.; Wolfe, B. Leslie // American Biology Teacher;Feb99, Vol. 61 Issue 2, p137
Provides information on a laboratory school activity about sickle-cell anemia. Symptoms of an irregularly shaped blood cells; Materials; Instructions on how to organize a role play, to demonstrate the theory behind electrophoresis.
- Age Influences Prevalence of Malb in Childhood Sickle Cell Disease. // Kidney;Mar/Apr99, Vol. 8 Issue 2, p66
Determines the prevalence of microalbuminuria (Malb) in children with homozygous sickle cell disease (HbSS), and to determine factors associated with increased prevalence. Prvalence of Malb in the age group 10-18 years; Prevalence of Malb in adults by the second decade of life.
- New hope for children with sickle cell disease. Segal, M. // FDA Consumer;Mar1989, Vol. 23 Issue 2, p14
Reports on new treatments for sickle cell anemia, a disease which primarily affects black children. Eight percent of black Americans carry a gene for sickle hemoglobin and one in every 400 black newborns in the US has sickle cell anemia or a related disease; Symptoms; Special problems in...