Pharmacological Basis for Use of Calcium Channel Antagonists in Hypertension

Scriabine, A.; Kazda, S.; Garthoff, B.; Nickerson, P.A.
January 1988
Angiology;Jan1988 Part 2, Vol. 39 Issue 1, p94
Academic Journal
The major mechanism of antihypertensive action of Ca2+ channel antagonists is the inhibition of Ca2+ entry into the vascular smooth muscle cell. Ca2+ channels are stabilized by these drugs in a mode unavailable for opening. The inhibition of Ca2+ entry leads to vasodilatation and lowering of arterial pressure. The advantages of Ca2+ channel antagonists in hypertension include improvement of blood supply to vital organs, diuretic activity, coronary vasodilatation, reduction in heart size and vascular cytoprotective effect.


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