Nitrendipine in the Treatment of Mild to Moderate Hypertension

Moser, Marvin
January 1988
Angiology;Jan1988 Part 2, Vol. 39 Issue 1, p73
Academic Journal
Studies have demonstrated that the calcium entry blockers are effective anti-hypertensive drugs, both in severe and in mild to moderately severe hypertension.1.2 Animal and human data have also demonstrated that the reduction in vascular resistance that occurs when these agents are administered not only results in lowered blood pressure but in a reduction in left ventricular mass.3,4 Most reports regarding efficacy of the calcium blockers have concerned themselves with the three available compounds in the United States, nifedipine, diltiazem and verapamil.5 Recent studies with nitrendipine, a new calcium entry blocker related chemically to nifedipine, indicate that it may also be an effective antihypertensive agent, with the advantages of the rapid onset of action of nifedipine and a long duration of action similar to verapamil.6 In addition, there is evidence that nitrendipine may reduce pre-load, in addition to afterload, with a minimal effect upon heart rate.


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