Baue, Arthur E.; Chaudry, Irshad H.; M. A. Wurth; Sayeed, M. M.
January 1974
Angiology;Jan1974, Vol. 25 Issue 1, p31
Academic Journal
A series of studies of progressive alterations in cell functions with hemorrhagic shock have been presented. These consist of decreases in the capability of mitochondria, alterations in mitochondrial cation content, increased Na+K-ATPase activity, depressed cell membrane transport of Na and K, decreased energy content of cells including less ATP and nonspecific hydrolysis of ADP and AMP, decreased responsiveness of the cell membrane to insulin to increase glucose uptake and increased survival when animals with hemorrhagic shock are given ATP combined with MgCl2. These studies combine with those from other laboratories allowed the development of an initial tentative hypothesis of progressive cell deterioration with shock. These studies provide: 1. Basic knowledge of the progressive alterations in cell function which occur with diminished circulation. 2. They provide for the possibility of supporting cell function in such circumstances by biochemical and pharmacological means. 3. They provide increased knowledge necessary for further developments in cryobiology and extracorporeal circulation.


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