A New Syndrome: Angiotensin-Converting Enzyme Dysfunction Syndrome: Differential Diagnosis and Pathogenesis--Case Reports

Umeki, Shigenobu; Terao, Akira; Sawayama, Toshitami
January 1988
Angiology;Jan1988 Part 1, Vol. 39 Issue 1, p58
Academic Journal
The authors previously reported a new syndrome, angiotensin-converting enzyme dysfunction syndrome (ACEDS), which is clinically characterized by mild systemic hypertension, a hypokalemic alkalosis, and hyperreninism with a high concentration of angiotensin-I (ANG-I), a normal angiotensin-II (ANG-II) value, and a normal aldosterone level. In the present study, they investigated the diagnosis and differentiation of diseases concomitant with hyperreninism, such as ACEDS, Bartter's syndrome, familial periodic paralysis, and renovascular hypertension treated with captopril for two months, and discussed the pathogenesis of ACEDS.


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