Platelet Hyperaggregability, Blood Prostacyclin and Dipyridamole

Solvay, H.; Kahn, M.; Cloarec, M.; Van De Merckt, J.; Sneppe, R.; Schram, E.; Fenollar, J.V.
March 1986
Angiology;Mar1986 Part 1, Vol. 37 Issue 3, p175
Academic Journal
This study demonstrates the presence of PGI2 in blood and its influence on platelet retention tests, possibly by the intermediate of a releasing system in the columns, which is followed by a proximate recuperation on the erythrocyte sites after the passage. The presence of prostacyclin on the erythrocyte sites seems to depend upon the red cell deformability in relation to the good condition of their erythrycote ATP reserve. The load of the erythrocyte sites increases with the daily dose of dipyridamole. The maximum load of the sites appears to be reached with a daily dose of dipyridamole 45Pmg. Approximately 10% of the atherosclerosis patients who have been treated by dipyridamole keep their platelet hyperaggregability and their abnormally lowered prostacyclin level.


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