Effect of Pindolol and Propranolol on Sinus Node Recovery Time and Atrioventricular Conduction Intervals

Kostis, John B.; Binenbaum, Steve Z.; Oliveri, Philip; Sclar, Craig; Hosler, Maryhelen
June 1987
Angiology;Jun1987, Vol. 38 Issue 6, p427
Academic Journal
In a randomized, observer-blind study, the effect of incremental doses of pindolol 0.001, 0.002, 0.003, and 0.004 mg/kg IV and propranolol 0.01, 0.02, 0.03, and 0.04 mg/kg IV on SA nodal recovery time (SNRT) and atrioventricular conduction interval (AH) was assessed in 20 patients (15 men and 5 women age range thirty to seventy-two, mean age fifty-three). AH and His bundle-to-ventricle (HV) intervals and SNRT were measured at spontaneous heart rate and at incremental atrial pacing rates (80, 100, 120, 140 bpm). Both drugs caused significant beta blockade as estimated by the percentage suppression of heart rate increment induced by 3 mcg isoproterenol administered intravenously (pindolol 67.6±5.3%, P<0.007; propranolol 38.6±10.6%, P<0.001). Propranolol significantly prolonged SNRT (P<0.05) and AH interval (P<0.05). Pindolol did not significantly affect either SNRT (P=0.25) or AH intervals (P=0.78). Significant effects on HV interval were not seen. Thus, in the doses tested that resulted in significant beta blockade, propranolol prolonged SA nodal recovery times and depressed AV nodal conduction while pindolol did not affect these variables.


Related Articles

  • SA node.  // Taber's Cyclopedic Medical Dictionary;2005, p1942 

    The article presents a definition for the term "SA node," which refers to sinoatrial node of the heart.

  • THE DELAY IN TRANSMISSION OF THE ATRIAL IMPULSE TO THE VENTRICLE. Di Palma, Joseph R. // Angiology;Aug1958, Vol. 9 Issue 4, p219 

    Two direct atrial action potentials were recorded in the anesthetized dog. One potential was made at the SA node as a monophasic current; the other was made at the area of the AV node as a diphasic current. The time of excitation of the AV node could be seen on these records. Thus the following...

  • Stereologic study of the sinoatrial node of rats – age related changes. de Melo, Silvana Regina; de Souza, Romeu Rodrigues; Mandarim-de-Lacerda, Carlos Alberto // Biogerontology;Dec2002, Vol. 3 Issue 6, p383 

    Changes in the sinoatrial node represent the major mechanism of sudden death in humans, and because of the sparse knowledge about the effects of aging on this structure, light microscopic and quantitative studies of the sinoatrial node were undertaken. Twenty-one hearts were studied, seven rat...

  • 3D reconstruction of the human cardiac conduction system based on micro-CT and histology. Atkinson, A.; Nikolaidou, T.; Boyett, M. R.; Dobrzynski, H. // Proceedings of the Physiological Society;2013, p817P 

    Introduction 3D computer models of the heart are important tools for teaching, research and drug discovery. In current human heart models, the heart's wiring system (the cardiac conduction system, CCS) is oversimplified or omitted and the aim of this study is to create a 3D model including the...

  • atrioventricular node. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p78 

    An encyclopedia entry for "atrioventricular node" is presented. It refers to a small knot of specialized muscle cells in the right atrium of the heart. It explains the mechanism by which the atrioventricular node and electrical impulses from the sinoatrial node enables the contraction of the...

  • Influence of Short Atrioventricular Delay on Late Diastolic Transmitral Flow and Stroke Volume. Ronaszeki, Aladar; Denef, Boudewijn; Ector, Hugo; Aubert, Andre E.; Werf, Frans Van De; De Geest, Hilaire // Angiology;Jan1992, Vol. 43 Issue 1, p32 

    Atrial transport function and the corresponding transmitral flow and stroke volume depend on the timing of atrial contraction. To study the influence of short atrioventricular delay (AVD) on these hemodynamic parameters, transmitral flow velocity (by pulsed wave Doppler) and aortic flow (by...

  • Spectral Energy of ECG Morphologic Differences to Predict Death. Phil Sung; Benjamin Scirica; David Morrow; John Guttag // Cardiovascular Engineering: An International Journal;Mar2009, Vol. 9 Issue 1, p18 

    Abstract  Unstable conduction system bifurcations following ischemia and infarction are associated with variations in the electrocardiographic activity spanning the heart beat. In this paper, we investigate a spectral energy measure of morphologic differences (SE-MD) that quantifies...

  • A Combination of Atrioventricular Block and Sinoatrial Block in a Horse. Rezakhani, A.; Godarzi, M.; Naeini, I. Tabatabei // Acta Veterinaria Scandinavica;2005, Vol. 46, p173 

    The article presents a study on the process of carrying out a routine check up examination on a group of horses of a riding school in Shiraz, Iran. It is a horse demonstrated frequent long pauses in heart rate of 33 beats per minute on auscultation. A base apex electrocardiogram was recorded to...

  • The diverse cardiac morphology seen in hearts with isomerism of the atrial appendages with reference to the disposition of the specialised conduction system. Smith, Audrey; Siew Yen Ho; Anderson, Robert H.; Connell, M. Gwen; Arnold, Robert; Wilkinson, James L.; Cook, Andrew C. // Cardiology in the Young;Oct2006, Vol. 16 Issue 5, p437 

    Congenital cardiac malformations which include isomerism of the atrial appendages are amongst the most challenging of problems for diagnosis and also for medical and surgical management. The nomenclature for pathological description is controversial, but difficulties can be overcome by the use...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics