TITLE

Effect of Pindolol and Propranolol on Sinus Node Recovery Time and Atrioventricular Conduction Intervals

AUTHOR(S)
Kostis, John B.; Binenbaum, Steve Z.; Oliveri, Philip; Sclar, Craig; Hosler, Maryhelen
PUB. DATE
June 1987
SOURCE
Angiology;Jun1987, Vol. 38 Issue 6, p427
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In a randomized, observer-blind study, the effect of incremental doses of pindolol 0.001, 0.002, 0.003, and 0.004 mg/kg IV and propranolol 0.01, 0.02, 0.03, and 0.04 mg/kg IV on SA nodal recovery time (SNRT) and atrioventricular conduction interval (AH) was assessed in 20 patients (15 men and 5 women age range thirty to seventy-two, mean age fifty-three). AH and His bundle-to-ventricle (HV) intervals and SNRT were measured at spontaneous heart rate and at incremental atrial pacing rates (80, 100, 120, 140 bpm). Both drugs caused significant beta blockade as estimated by the percentage suppression of heart rate increment induced by 3 mcg isoproterenol administered intravenously (pindolol 67.6±5.3%, P<0.007; propranolol 38.6±10.6%, P<0.001). Propranolol significantly prolonged SNRT (P<0.05) and AH interval (P<0.05). Pindolol did not significantly affect either SNRT (P=0.25) or AH intervals (P=0.78). Significant effects on HV interval were not seen. Thus, in the doses tested that resulted in significant beta blockade, propranolol prolonged SA nodal recovery times and depressed AV nodal conduction while pindolol did not affect these variables.
ACCESSION #
16353052

 

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