The Influence of Sympathetic Nerves on Transcutaneous Oxygen Tension in Normal and Ischemic Lower Extremities

Rooke, Thom W.; Holler, Larry H.; Osmundson, Philip J.
May 1987
Angiology;May1987, Vol. 38 Issue 5, p400
Academic Journal
The authors evaluated the relationship between sympathetic nerve activity and transcutaneous oxygen tension (TcpO2) in normal and ischemic lower extremities. Dorsal foot TcpO2 was measured by using oxygen-sensing electrodes with surface temperatures of 42°C and 45°C; in theory, changes in sympathetic activity should affect vasomotor tone and TcpO2 in skin beneath an electrode at 42°C (submaximal vasodilation), but not at 45°C (maximal vasodilation). The vasodilation index (TcpO2 at 42°C/TcpO2 at 45°C) was created as an index of vasomotor tone (vasodilation index increases as tone decreases). In normal limbs (n=24) averages for TcpO2 at 42°C, TcpO2 at 45°C, and vasodilation index were 30.3 mmHg, 62.1 mmHg, and 0.47, respectively. In subjects (n=5) with quadriplegia and reduced sympathetic tone secondary to cervical cord trauma, TcpO2 at 42°C and vasodilation index were increased (45.0 mmHg and 0.61); TcpO2 at 45°C did not change. When normal subjects (n=7) were chilled for twenty minutes with a cooling blanket at 5°C (to increase sympathetic tone) average vasodilation index dropped from 0.50 to 0.29. Among ischemic limbs (n=34) vasodilation index was highly variable (range: 0–0.77); in general, vaso- dilation index fell as the ischemia worsened. In a subset of patients with ischemic limbs, the vasodilation index increased after the limb was wrapped in a warm dressing (average vasodilation index=0.25 without dressing, 0.37 with dressing). The authors conclude: (1) TcpO2 can be used to assess the degree of vasomotor tone (and sympathetic activity) in skin; (2) tone generally increases as ischemia worsens; and (3) local warmth can improve cutaneous circulation in ischemic limbs.


Related Articles

  • EVALUATION OF LOCAL ISCHEMIA, GENERAL ANOXIA, AND VASODILATORS IN REACTIVE HYPEREMIA. Geber, William F.; Schwinghamer, James M. // Angiology;May1965, Vol. 16 Issue 5, p256 

    The relationship of local ischemia, general anoxia and vasodilator metabolites to the production of reactive hyperemia has been investigated utilizing the vasculature of the hind limb of the dog. The oxygen tension of the circulating blood was reduced to extremely low values by the techniques of...

  • Microvascular Reactivity After Ischemia/Reperfusion in the Hamster Cheek Pouch: Beneficial Effects of Different Oral Doses of S-5682 (Daflon 500 mg). Bouskela, Eliete; Cyrino, Fatima Z. G. A.; Lerond, Laurence // Angiology;Jan1997, Vol. 48 Issue 1, p33 

    Daflon 500 mg (S-5682) is a purified, micronized flavonoid fraction containing 90% diosmin and 10% hesperidin that is currently used to treat chronic venous insufficiency and hemorrhoidal disease. Thus, it seemed of interest to evaluate the effects of S-5682 on ischemia/reperfusion, ie, the...

  • Pharmacological Basis for Use of Calcium Channel Antagonists in Hypertension. Scriabine, A.; Kazda, S.; Garthoff, B.; Nickerson, P.A. // Angiology;Jan1988 Part 2, Vol. 39 Issue 1, p94 

    The major mechanism of antihypertensive action of Ca2+ channel antagonists is the inhibition of Ca2+ entry into the vascular smooth muscle cell. Ca2+ channels are stabilized by these drugs in a mode unavailable for opening. The inhibition of Ca2+ entry leads to vasodilatation and lowering of...

  • Small artery remodelling in hypertension: causes, consequences and therapeutic implications. Mulvany, Michael J. // Medical & Biological Engineering & Computing;May2008, Vol. 46 Issue 5, p461 

    Essential hypertension is treated primarily with a view to reducing blood pressure, and not with regard to normalizing the main pathological changes: the peripheral resistance and the cardiovascular structure. The aim of this review is to discuss whether normalization of the latter parameters,...

  • Economic Evaluation of Nebivolol in the Treatment of Hypertension. Kaltwasser, Maria Theresia // American Journal of Cardiovascular Drugs;2005, Vol. 5 Issue 5, p319 

    Objective: To examine the economic consequences of effective antihypertensive treatment using the novel vasodilating β1-adrenoceptor antagonist nebivolol (Nebilet®) from the perspective of the healthcare provider. Methods: The evaluation was based on a postmarketing surveillance study in...

  • A novel echocardiographic method as an indicator of endothelial dysfunction in patients with coronary slow flow. SIMSEK, H.; SAHIN, M.; GUNES, Y.; AKDAG, S.; AKIL, M. A.; AKYOL, A.; GUMRUKCUOGLU, H. A.; YAMAN, M. // European Review for Medical & Pharmacological Sciences;Mar2013, Vol. 17 Issue 5, p689 

    BACKGROUND: To improve clinical outcomes, noninvasive imaging modalities have been proposed to measure and monitor atherosclerosis. Endothelial dysfunction is considered the first stage in the development of atherosclerosis. Brachial artery flow-mediated dilatation (FMD) has been impaired in...

  • TIA--Treacherously Inaccurate Acronym. Fred, Herbert L. // Texas Heart Institute Journal;2002, Vol. 29 Issue 4, p314 

    Deals with the difficulty of diagnosing transient ischemic attacks (TIA). Nonvascular disorders mimicking TIA.

  • Ischemia and intersecting stapling: the Achilles' heel of problematic low rectal anastomoses. Tang, W.-H.; Friess, H. // Techniques in Coloproctology;Aug2013, Vol. 17 Issue 4, p463 

    A letter to the editor is presented related to ischemia and intersecting stapling.

  • A NEW VASODILATING AND ANTISPASMODIC AGENT: ISOXSUPRINE HYDROCHLORIDE. Kaindl, F.; Samuels, S. S.; Selman, D.; Shaftel, H. // Angiology;Aug1959 Part 1, Vol. 10 Issue 4, p185 

    Isoxsuprine (Vasodilan) is an effective and safe drug, at the recommended dosages, for symptomatic treatment of patients suffering from any of several disorders of peripheral or intracraneal circulation. This statement is supported by published reports and by our own experience. In addition...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics