TITLE

Hypotensive Effects of Nifedipine in Patients with Primary Hyperparathyroidism: Case Reports

AUTHOR(S)
Takata, Yutaka; Takishita, Shuichi; Koga, Tokushi; Nakao, Yae; Okamura, Ken; Yao, Takashi; Takemura, Ken; Fujishima, Masatoshi
PUB. DATE
December 1989
SOURCE
Angiology;Dec1989, Vol. 40 Issue 12, p1079
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Nifedipine was administered orally to 2 patients with primary hyperparathy- roidism before and after parathyroidectomy. The operation lowered serum calcium concentration and parathyroid hormone but did not alter plasma renin activity, plasma aldosterone concentration, and serum magnesium. The hypotensive effects of nifedipine were markedly enhanced with the decrease in serum calcium concentration following parathyroidectomy. Thus, the level of serum calcium concentration may modulate the hypotensive effect of nifedipine in humans.
ACCESSION #
16352997

 

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