TITLE

VASCULAR EFFECTS OF DIHYDROGENATED ERGOT ALKALOIDS

AUTHOR(S)
Ulrich, J.; Siggaard-Andersen, J.
PUB. DATE
December 1971
SOURCE
Angiology;Dec1971, Vol. 22 Issue 11, p622
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The effect of dihydroergostine, DE 145 (Sandoz), and dihydroergotamine. DHE, on the blood flow and the capacitance vessels was examined in a comparative, quantitative study, carried out on the right calf of 14 normal adults by aid of plethysmography. The two drugs elicited dissimilar responses in the vascular bed, DE 145 elicited a significant increase in the resting blood flow of 24 per cent, while DHE did not influence the resting blood flow significantly. DHE produced a constrictor response of the capacitance vessels, giving a significant reduction in the calf volume of 4 ml per liter. DE 145 did not affect the capacitance vessels.
ACCESSION #
16352995

 

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