Whole Blood and Red Cell ATP Content in Patients With Peripheral Vascular Disease: The Effect of Cigarette Smoking and Oxpentifylline

Maughan, Ronald J.; Broom, John; Smith, George; Leiper, John B.; Ah-See, Antoine K.; Engeset, Jetmund; Evan-Wong, Alex; Davidson, Ronald J. L.
October 1984
Angiology;Oct1984, Vol. 35 Issue 10, p628
Academic Journal
The relationship between erythrocyte ATP content and the presence of atherosclerotic peripheral occlusive vascular disease was investigated. In 20 elderly patients with severe peripheral vascular insufficiency (10 male, 10 female; age 68.8 � 12.5 years; Mean � SD) the mean erythrocyte ATP content was 1.57 � 0.16 mmol/litre. In a sex and age matched group (69.1 � 9 . 6 years) with no signs or symptoms of peripheral or myocardial ischaemia, erythrocyte ATP content did not differ significantly (1.49 � 0.29 mmol/litre). In young healthy volunteers, there was no difference in erythrocyte ATP content between males and females or between cigarette smokers and non-smokers, nor were the values for the young group different from those obtained from the elderly patients. The effect of Oxpentifylline administration on erythrocyte ATP levels in patients with peripheral vascular disease was also studied. Administration of Oxpentifylline (1.6 g per day in divided doses) over 7 days had no effect on erythrocyte ATP content in 10 patients (5 male, 5 female) with ischaemic lower limbs. These results suggest that measurement of erythrocyte ATP content is unlikely to be a useful index in the assessment of peripheral vascular disease.


Related Articles

  • Peripheral Vascular Care: Should You Have a "Vascular Center"? Sallo, Barbara // Journal of Cardiovascular Management;Jul/Aug2004, Vol. 15 Issue 4, p18 

    Cardiovascular care is big business for hospitals. Although a lot of attention and resources are directed to care and treatment of the coronary arteries, peripheral vascular disease (PVD) care has gained momentum. Even though the dollars spent on PVD care are significantly less than for cardiac,...

  • FYi.  // Consumer Reports on Health;Aug2002, Vol. 14 Issue 8, p2 

    Presents information on health-related subjects. Indications that calf pain while walking is a sign of peripheral vascular disease; Web site suggested to settle disputes with health plan providers.

  • MEDICAL MANAGEMENT OF PERIPHERAL VASCULAR DISEASE. Iglaurer, Arnold // Angiology;Feb1958, Vol. 9 Issue 1, p11 

    Discusses various medical management of peripheral vascular diseases. Effect of diet on atherosclerosis; Contraindication of the use of tobacco in thromboangiitis obliterans; Identification of drugs that can be taken to relieve night pain and cramps.

  • Percutaneous Interventions for Lower Extremity Peripheral Vascular Disease. De Sanctis, Julia Tucker // American Family Physician;12/15/2001, Vol. 64 Issue 12, p1965 

    Peripheral vascular disease of the lower extremities is an important cause of morbidity that affects up to 10 million people in the United States. The primary care physician can easily identify patients who are at risk for the disease with a questionnaire and a relatively simple test--the ankle...

  • CLINICAL ABSTRACTS: vascular disease.  // Modern Medicine;Feb99, Vol. 67 Issue 2, p36 

    Presents several abstracts on vascular disease. `Vessel Size and Long-Term Outcome after Coronary Stent Placement,' by S. Elezi, A. Kastrati, F-J Neumann et al.; `Treating to Meet NCEP-Recommended LDL Cholesterol Concentrations with Atorvastatin, Fluvastatin, Lovastati, or Simvastatin in...

  • Don't take leg pain lying down.  // Better Homes & Gardens;Mar2000, Vol. 78 Issue 3, p230 

    Provides information on causes, symptoms and treatment for peripheral vascular disease (PVD). Blocking of leg arteries by cholesterol or calcium; Doctors' recommendation for patients to stop smoking and watch their diets; Lowering of cholesterol and blood pressure; Test to diagnose PVD.

  • peripheral arterial disease.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1752 

    An encyclopedia entry for "peripheral arterial disease," is presented.

  • peripheral vascular disease.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1752 

    An encyclopedia entry for "peripheral vascular disease," is presented.

  • Prevalence and Risk Factors of Peripheral Vascular Disease in a Selected South Indian Population. Premalatha, Gopal; Shanthirani, Subramaniam; Deepa, Raj; Markovitz, Jerome; Moran, Viswanathan // Diabetes Care;Sep2000, Vol. 23 Issue 9, p1295 

    Presents information on a study which determined the prevalence and risk factors of peripheral vascular disease among South Indians. Research design and methods; Results; Conclusions.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics