TITLE

Ineffectiveness of Ca2+-Antagonists Nicardipine and Diltiazem on Experimental Atherosclerosis in Cholesterol-fed Rabbits

AUTHOR(S)
Naito, Michitaka; Kuzuya, Fumio; Asai, Kan-ichi; Shibata, Kazuaki; Yoshimine, Noboru
PUB. DATE
October 1984
SOURCE
Angiology;Oct1984, Vol. 35 Issue 10, p622
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
There is accumulating evidence that calcium metabolism plays an important role in the pathogenesis of atherosclerosis. The inhibitory effect of nifedipine, a Ca�-antagonist, on experimental atherosclerosis in cholesterol-fed rabbits has been reported, and we examined the anti-atherosclerotic action of nicardipine and diltiazem, similar Ca2+-antagonists, but no inhibitory action was observed. It is necessary to recognize the fact that the sensitivity of rabbits to an antiatherogenic diet shows great individual differences. For the purpose of preventing atherosclerosis due to the abnormality of lipid metabolism the use of Ca2+-antagonist is not warranted at the present stage.
ACCESSION #
16352929

 

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