Bartoli, V.; Dorigo, B.; Tedeschi, E.; Biti, G. P.; Voegelin, M. R.
April 1970
Angiology;Apr1970, Vol. 21 Issue 4, p215
Academic Journal
The best-fit method was applied to data of calf basal resting and reactive hyperemia blood flow, recorded at 4-hr, intervals during a day in 15 patients with intermittent claudication. The mathematical-statistical analysis suggests existence of a circadian rhythm of calf blood flow, which has early evening peaks and a nocturnal trough with a nadir occurring after midnight and before 4 a.m. This rhythm displays marked similarities to those of all other circulatory values. It is hard to decide whether or not the mechanism of rhythm has an independent endogenous origin. It is known that many of the circulatory variables are interrelated and that some are clearly related to other circadian rhythms. Perhaps the rhythmic reduction of limb blood flow, which begins during the night, is the mechanism underlying the nocturnal pain of subjects with limb ischemia by peripheral arterial disease.


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