Leg Blood Flow in Intermittent Claudication -- A Comparison Between Non Insulin Dependent Diabetics and Non Diabetics

Janzon, Lars; Bergentz, Sven-Erik; Ericsson, Bjorn F.; Hanson, Martin; Lindell, Sven-Eric
November 1984
Angiology;Nov1984, Vol. 35 Issue 11, p724
Academic Journal
The influence of diabetes on leg blood flow in intermittent claudication has been assessed by comparing the systolic arm-ankle pressure gradient at rest and resistance to blood flow during reactive hyperemia in patients with non-insulin dependent diabetes and non-diabetic controls. Cases and controls were matched for age and sex. Smoking habits, blood pressure, and blood lipids didn't differ in the two groups. Diabetes was associated with a higher resistance to blood flow during reactive hyperemia and a greater arm-ankle pressure gradient at rest. Resistance to blood flow during reactive hyperemia was in the non-diabetics strongly correlated to the arm-ankle pressure gradient at rest (r=0.84). Corresponding correlation coefficient was in diabetics 0.04. In one of four diabetic legs a high resistance to blood flow during reactive hyperemia didn't correspond to a big arm-ankle pressure gradient. The results in this study support the concept of both macro- and microvascular disease in diabetes.


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