Common, Herbert H.; Seaman, Arthur J.; R�sch, Josef; Porter, John M.; Dotter, Charles T.
November 1976
Angiology;Nov1976, Vol. 27 Issue 11, p645
Academic Journal
Twenty-seven patients with deep vein thrombosis whose primary therapy was randomized between streptokinase and heparin were reevaluated clinically and by ascending venography after a mean period of 7 months. Normal venograms were found in 6 (40%) of the streptokinase-treated patients and in I patient (8%) who had heparin therapy. Segmental valve preservation was found in 1 patient from each group. All patients with complete or partial valve preservation became asymptomatic. Vein recanalization without preservation of valves occurred in 18 patients: 8 (54%) of those on streptokinase, and 10 (83%) of those on heparin. At the time of follow-up, 11 of these 18 patients, including 8 who had had prior thrombosis, reported peripheral edema; the postphlebitic syndrome developed in I. Factors favoring a good outcome of acute venous thrombosis were (I) no prior thrombotic disease, (2) localized thrombosis, and (3) prompt streptokinase therapy.


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