The Role of Fibrinolysis in the Therapy of Peripheral Vascular Disease

Ambrus, Clara M.; Ambrus, Julian L.; Gastpar, Helmuth; Sharma, Satya D.; Suh, O. W.; Moore, Robert H.; Williams, Phyllis
July 1984
Angiology;Jul1984, Vol. 35 Issue 7, p436
Academic Journal
In vivo thrombolytic studies in stumptailed monkeys indicated that pentoxifylline potentiates thrombolysis induced by urokinase activated human plasmin. Pentoxifylline as well as prostaglandin E1 released plasminogen activators and activated the fibrinolysin system. From this point of view pentoxifylline and prostaglandin E1 synergized with each other. Pentoxifylline potentiated the thrombolytic effect of prostaglandin E1 in vivo.


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