Hypertensive Crisis Induced by Metoclopramide in Patient with Pheochromocytoma

Abe, Masayoshi; Orita, Yasuhiko; Nakashima, Yasuhide; Nakarnura, Motoomi
February 1984
Angiology;Feb1984, Vol. 35 Issue 2, p122
Academic Journal
A hypertensive crisis associated with evidence of catecholamine release was induced following intravenous administration of 10 mg metoclopramide in a woman with pheochromocytoma and in whom the tyramine test was negative. After removal of the tumor, blood-pressure and plasma catecholamine concentrations were not influenced by the administration of metoclopramide. It is suggested that the mechanism of hypertensive crises induced by metoclopramide may not be due to a direct catecholamine releasing effect from the tumor or sympathetic nerve endings, but rather to its presynaptic dopaminergic blocking effect which would indirectly release catecholamines.


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