Intracavernous Injection of Papaverine as a Diagnostic and Therapeutic Method in Erectile Failure

Virag, R.; Frydman, D.; Legman, M.; Virag, H.
February 1984
Angiology;Feb1984, Vol. 35 Issue 2, p79
Academic Journal
The effect of intracavernous injection of papaverine (ICIP) has been investigated in 45 men: 6 normally potent volunteers, 10 psychogenic, and 29 organic impotent males. The first two groups obtained erections within 10 minutes, lasting from 1 to 4 hours, after injection of 80 mg of papaverine. Those belonging to the organic group experienced delayed, weaker and shorter erections, related to various degrees of arterial and/or veinous and neurologic lesions. Haemodynamic and radiologic studies done concomitantly, showed a strong vasodilation in the penile arteries (even when pathologic) and a diminished outflow from the cavernous bodies. Subsequently, a pilot study was performed in a series of 63 patients suffering from various degrees of angiogenic impotence, in order to study the therapeutic effect of repeated intracavernous injections of papaverine completed by intracavernous infusion of heparinized saline. Erections improved significantly in 66% of the patients with a mean follow up of one year.


Related Articles

  • Sexual dysfunction in men after open or endovascular repair of abdominal aortic aneurysms. Jimenez, Juan Carlos; Smith, Melissa M.; Wilson, Samuel Eric // Vascular;May/Jun2004, Vol. 12 Issue 3, p186 

    Few studies have thoroughly investigated the incidence and detailed the degree of sexual disability after aortic aneurysm surgery. Reports prior to 1990 vary greatly in the incidence of postoperative dysfunction mostly because of nonstandardized methods of assessment. In this article, we compare...

  • Can self-administered questionnaires supplant objective testing of erectile function? A comparison between the international index of erectile function and objective studies. Melman, A.; Fogarty, J.; Hafron, J. // International Journal of Impotence Research;Mar/Apr2006, Vol. 18 Issue 2, p126 

    To determine whether the results of the self-reported International Index of Erectile Function (IIEF) to assess erectile function can overestimate the degree of erectile impairment. A total of 32 consecutive patients seeking treatment for erectile dysfunction (ED) at a urologist's office were...

  • Candesartan cilexetil protects cavernous tissue in spontaneously hypertensive rats. Toblli, J. E.; Stella, I.; Mazza, O. N.; Ferder, L.; Inserra, F. // International Journal of Impotence Research;Aug2004, Vol. 16 Issue 4, p305 

    In previous experiments, our group demonstrated morphological changes in erectile tissue from male spontaneously hypertensive rats (SHR). The present study was performed to determine whether an angiotensin II receptor blocker could protect cavernous tissue (CT) from these structural alterations...

  • Approach to post-RP PDE-5 inhibitors inconsequential. Petrou, Ilya // Urology Times;5/15/2006, Vol. 34 Issue 6, p42 

    The article presents the results of a study conducted by Italian researchers on sexual dysfunction in men. According to the study, when administering phosphodiesterase type-5 inhibitor therapy in men who have undergone radical prostatectomy, rehabilitative therapy is equally effective. Urologist...

  • Opilon.  // Royal Society of Medicine: Medicines;2002, p409 

    The article presents information on Opilon which is a proprietary, prescription-only preparation of the alpha-adrenoceptor blocker moxisylyte (thymoxamine; as hydrochloride), which has vasodilator properties. It can be used to treat peripheral vascular disease (primary Raynaud's phenomenon),...

  • Impotence strikes two in three over 45.  // New Zealand Doctor;8/14/2013, p38 

    The article offers information on a study which reveals a high incidents of impotence to men aged 45 years old and above.

  • Sexual Chemistry. Mestel, Rosie // Discover;Jan1999, Vol. 20 Issue 1, p32 

    Reports on the testing of the anti-impotence drug Viagra in 1998. Results of experiments on impotent men who took the drug; Government approvals of the drug; Mechanism of action; Success rate of the drug.

  • Twenty years of IJIR. Seftel, A D // International Journal of Impotence Research;Sep/Oct2008, Vol. 20 Issue 5, p429 

    The article introduces the special commemorative 20th anniversary issue of "International Journal of Impotence Research."

  • Erectile/sexual dysfunction news in brief.  // Urology Times;Nov2003, Vol. 31 Issue 11, p28 

    Presents news on erectile and sexual dysfunction and treatment recent as of November 2003. Improvement in erectile function following administration of vardenafil; Physiological effectiveness of sildenafil citrate; Drug preparation for using low-doses of antibodies to endothelial nitric oxide...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics