Buflomedil in Arterial Occlusive Disease: Results of a Controlled Multicenter Study

Trubestein, G.; Balzer, K.; Bisler, H.; Kluken, N.; Muller-Wiefel, H.; Unkel, B.; Mahfoud, Y.; Ziegler, W.
August 1984
Angiology;Aug1984, Vol. 35 Issue 8, p500
Academic Journal
In a double-blind, randomised multicentre study buflomedii, a vasoactive substance, was compared with placebo in the treatment of 93 patients with chronic arterial occlusive disease. After a run-in period of four weeks the patients received either buflomedil (600 mg daily) or placebo over 12 weeks. The pain-free and the total walking distances improved significantly in both groups. However, the differences in the improvement between the two groups were highly significant and in favour of buflomedil: for the pain-free walking distance p<0.001 and for the total walking distance p<0.01. The results indicate that buflomedil bas a beneficial effect on the symptoms and lengthens the walking distance in patients with arterial occlusive disease.


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