TITLE

Efficacy and Safety of Pentoxifylline in Geriatric Patients with Intermittent Claudication

AUTHOR(S)
Crowder, John E.; Cohn, Jay B.; Savitsky, J. Philip; Morgan, DeAnn L.; Slywka, Joseph; Cobert, Barton L.; Hryniewicki, Stephen W.; Piccirillo, Ronald T.; Wilcox, Charles S.
PUB. DATE
September 1989
SOURCE
Angiology;Sep1989, Vol. 40 Issue 9, p795
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The effects of pentoxifylline on intermittent claudication were evaluated at a dose of 1200 mg/day in an open-label twelve-week study on geriatric patients with chronic occlusive arterial disease (COAD). Standardized treadmill testing and clinical signs and symptoms of COAD were followed up before and during drug administration. Twenty-four subjects with a mean age of 73.5 years, capable of walking between 20 and 200 meters on the treadmill, were entered into the trial; 22 participated for eight weeks and 19 completed the study in terms of treadmill walking distance measurements at 12 weeks. The mean walking distance for all patients was increased 111% over baseline at week 12. Thirteen subjects were considered drug responders (≥50% increase in treadmill walking distance) and 9 were considered nonresponders (<50% increase). Improvements in clinical signs and symptoms of COAD were noted. Decreases in elevated systemic systolic pressures (but not diastolic) were unexpectedly observed in many drug responders. Seven of 19 males reported sexual function improvements while receiving pentoxifylline. Fourteen (58%) of the 24 subjects reported mild side effects of dyspepsia, nausea, vomiting, dizziness, headache, or insomnia; no subjects were withdrawn from the study because of side effects. In summary, pentoxifylline improved function and symptoms in 13 of 22 geriatric patients with intermittent claudication; the drug was safe and well tolerated at the usual dosage in this geriatric patient population.
ACCESSION #
16352620

 

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