Clinical Experience With a Transdermal Nitroglycerin System

Mahapatra, Rajat K.; Mahapatra, Dipta; Yaden, Senka
April 1987
Angiology;Apr1987, Vol. 38 Issue 4, p277
Academic Journal
Forty-seven patients with chronic stable angina pectoris entered a thirteen-week open-label study with a transdermal therapeutic system of nitroglycerin in order to evaluate its clinical efficacy, safety, and patient acceptance. In 19 patients, a beta-blocker and in 17 patients a calcium-channel blocker were continued throughout the study period without alteration of their doses. The study consisted of a two-week run-in period and an eleven-week active drug period. Acute titration was done with nitroglycerin patches on the basis of weekly patient diaries on frequency of angina and sublingual nitroglycerin consumption. Overall, reductions in frequency of angina and in nitroglycerin consumption were statistically significant (p<0.05). Adverse reactions were common but tolerable. The reported side effects were headache in 32, skin rash in 18, dizziness in 10, palpitation and itching in 9 each, nausea in 7, flushing in 3, and vomiting in 1 patient. In conclusion, the present study demonstrates that individual dose titration with nitroglycerin patches for obtaining significant antianginal effect is essential. The present therapeutic system is convenient to use and well tolerated and had acceptable side effects in our study population.


Related Articles

  • Two new therapies relieve refractory chronic stable angina.  // Geriatrics;Jan98, Vol. 53 Issue 1, p26 

    Focuses on chronic stable angina and the utilization of two therapies as effective treatment. Description of methods; Details on studies conducted using the therapies; Discussion on findings.

  • Nitroglycerine: Solving a Century-Old Puzzle.  // Medical Update;Jun2002, Vol. 27 Issue 12, p4 

    Presents the findings of a study conducted by researchers at Duke University Medical Center which identified the enzyme responsible for the negative effects of nitroglycerine to patients with angina.

  • Oxcarbazepine is effective and safe in the treatment of neuropathic pain: pooled analysis of seven clinical studies. Magenta, P.; Arghetti, S.; Di Palma, F.; Jann, S.; Sterlicchio, M.; Bianconi, C.; Galimberti, V.; Osio, M.; Siciliano, G.; Cavallotti, G.; Sterzi, R. // Neurological Sciences;Oct2005, Vol. 26 Issue 4, p218 

    The results of 7 open-label clinical studies on oxcarbazepine (OXC) in different neuropathic pain conditions, sharing the same protocols, were pooled together in order to evaluate whether the results obtained in the individual trials were confirmed in the pooled analysis of this larger sample,...

  • nicorandil.  // Royal Society of Medicine: Medicines;2002, p390 

    This article presents information on nicorandil, a potassium-channel activator and vasolidator drug. It can be used to treat angina pectoris. It is administered orally. Known side effects include headache, cutaneous skin vasolidation with flushing, nausea, vomiting, dizziness and weakness. At...

  • Nitroglycerine in the treatment of heart attacks.  // Chemical Business;Dec2009, Vol. 23 Issue 12, p52 

    The article looks at the use of nitroglycerine in treating and preventing angina. Among the possible symptoms of the disease are shortness of breath and nausea or vomiting. In contrast to a heart attack, angina is diagnosed based on the results of a physical examination, an electrocardiogram and...

  • Patients' knowledge of sublingual glyceryl trinitrate. Bailie, George R.; Kay, Elizabeth A. // BMJ: British Medical Journal (International Edition);7/2/88, Vol. 297 Issue 6640, p32 

    Studies the use of sublingual glyceryl trinitrate to treat angina pectoris in patients. Evaluation on the knowledge of patients on the drug; Efficacy of tablet; Oral information and instructional material for the use of drug.

  • Diminished activity of glyceryl trinitrate. O'Hanrahan, M.; McGarry, K.; Kelly, J.G.; Horgan, J.; O'Malley, K. // British Medical Journal (Clinical Research Edition);4/17/1982, Vol. 284 Issue 6323, p1183 

    Examines glyceryl trinitrate as treatment for angina pectoris. Rapid relief offered by the drug; Importance of proper storage to maintain effectivity; Effects of drugs on the patient.

  • Antianginal combination reduces cardiac events, but causes headaches.  // Modern Medicine;Aug97, Vol. 65 Issue 8, p53 

    Presents an abstract of `Effect of Transdermal Nitroglycerin or N-acetylcysteine, or Both, in the Long-Term Treatment of Unstable Angina Pectoris,' by D. Ardissino, P.A. Merlini, et al from the `Journal of the American College of Cardiology' dated April 1997.

  • Risks associated with giving benzodiazepines to patients with acute nuerological injuries. Eldridge, P.R.; Punt, J.A.G. // BMJ: British Medical Journal (International Edition);5/5/90, Vol. 300 Issue 6733, p1189 

    Investigates the risks associated with benzodiazepines on patients with acute neurological injuries in Great Britain. Evaluation of patients with different neurological diseases; Details on the complications on patients; Effect of blood gas estimation on patients.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics