TITLE

Glucose and Erythrocyte ATP: Distinctive Effects of Dipyridamole and of Ticlopidine

AUTHOR(S)
Solvay, H.; Kahn, M.; Garreyn, S.; Cloarec, M.; Sneppe, R.; Schram, E.; Fenollar, J.V.
PUB. DATE
November 1987
SOURCE
Angiology;Nov1987, Vol. 38 Issue 11, p815
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This experiment suggests the following points: 1. Erythrocytes in control patients and in atherosclerosis patients seem to have a variable grade of affinity for adenosine and for plasma glucose. This variable grade seems to fix the level of the adenosine triphosphate (ATP) reserves and induces the erythrocytes' deformability. 2. The drop in the level of ATP reserves that induces the poor deformability of the erythrocytes in atherosclerosis patients would appear to be caused by two consecutive shortages: first a shortage that seems to be related to a deficiency of erythrocyte adenosine as the ATP shortage disappears with dipyridamole treatment and then a shortage induced by the lack of erythrocyte glucose and suppressed by the addition of ticlopidine to the dipyridamole treatment.
ACCESSION #
16352475

 

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