Hansteen, Viggo; Lorensten, Einar
June 1975
Angiology;Jun1975, Vol. 26 Issue 6, p458
Academic Journal
The effect of tolazoline on forefoot blood flow in patients with obliterative atherosclerosis has been compared after intra-arterial and intravenous injection. The forefoot blood flow increased considerably after injection in most of the patients. The flow increase was practically identical whether tolazoline was injected intra-arterially or intravenously, and was most marked in patients with moderate peripheral arterial insufficiency. The flow increase was accompanied by a significant augmentation of the systemic blood pressure. In the majority of the patients tolazoline also caused considerable reduction of the peripheral resistance of the foot both after intra-arterial and intravenous administration. The increase was, however, least�or was lacking�in patients with severe skin ischaemia. The collateral pressure gradient did not decrease after the injection of tolazoline. It is concluded that tolazoline may be a valuable drug in selected patients, although the effect is most uncertain in patients with the most urgent need for augmented flow. Intravenous administration of tolazoline should be preferred.


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