Thulesius, Olav; Gj�res, J. E.
February 1974
Angiology;Feb1974, Vol. 25 Issue 2, p145
Academic Journal
The present investigation reports about isometric contraction of isolated vein preparations obtained from normal subjects and patients with varicose veins. The spirally cut vein preparations represented various stages of wall changes due to increasing varicosity. The degree of local vascular changes was estimated according to an arbitrary rating scale of 0�3. Smooth muscle activity was evaluated by the magnitude of the contractile response and could be shown to be inversely related to the degree of local vascular changes. It was noteworthy that some degree contractility was preserved in many preparations with marked vascular changes. The apparently normal vessel preparations from patients with primary varicose veins and those from patients without varicose disorders exhibited a similar contractile pattern, which means that a primary deficiency of smooth muscle contractility cannot be an etiologic factor for the pathogenesis of primary varicose veins. Contractility was also compared in vessels with different location but from the same extremity. Here it could be shown, that the distal and superficial veins showed a more forceful contraction than the proximal and deep vessels. Finally the phenomenon of stress-relaxation or creep was more pronounced in ordinary vessels with a normal contractility than in vessels with varicose wall changes. Therefore stress relaxation in superficial veins seems to a great extent be related to the proper function of vascular smooth muscle.


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