Therapy of Atherosclerotic Arteriopathy of Lower Limbs Aspects and Results

Tesi, M.; Bronchi, G.F.; Carini, A.; Karavassili, M.
October 1985
Angiology;Oct1985, Vol. 36 Issue 10, p720
Academic Journal
As far as therapy is concerned, atherosclerotic arteriopathy may be divided into acute and chronic forms. In acute embolic forms, therapy should be surgical. Only in cases of peripheral embolism or polyembolism, and in rare cases for which vascular surgery cannot be adopted, can thrombolysis be carried out with UK. In acute thrombotic forms, therapy should be medical, because a thrombus of recent formation is rich in fibrin and may be lyzed by UK. Total recanalization takes place in 61% of cases treated, partial recanalization in 23%. Subsequently perviousness is maintained by adequate antithrombotic therapy. In chronic arteriopathy, the thrombus is lacking or almost lacking in fibrin and thrombolytic therapy is not indicated. Special therapeutic combinations are used containing platelet inhibitors (ticlopidine), antifibrin drugs (subcutaneous heparin), minor fibrinolytic agents (mesoglycan) and hemorheological drugs (pentoxyphylline). This therapy seems to give good results, as showed by the low percentage in amputation calculated on 2,565 patients treated and kept under observation for 5 years. Finally let us consider chronic progressive arteriopathy. This term indicates a very advanced stage, characterized by a gradual irreversible change for the worse leading towards gangrene. As a last resort, before amputating, a thrombolytic therapy with UK was tried to see if with strong fibrinolysis continued for 3 days amputation might be avoided. In a pilot study carried out on 12 patients, the angiographic data showed only partial lysis in small arteries or arterial branches. Clinical data showed reduction or disappearance of pain at rest in 80% of cases. In 70% of cases gangrene disappeared if it was initial and superficial, it was delimited if already in progress.


Related Articles

  • VASCULOPATIA CEREBRALE ISCHEMICA.  // Neuroradiology Journal;Oct2008 Supplement, Vol. 21, p61 

    The article provides information about intravenous thrombolysis. It states that intravenous thrombolysis was considered as the most important therapeutic achievement for ischemic stroke. It is discussed that the meta-analysis of large randomised clinical trials have demonstrated that the...

  • Barriers to delivery of thrombolysis for acute stroke. Barber, Mark; Langhorne, Peter; Scott, David J. // Age & Ageing;Mar2004, Vol. 33 Issue 2, p94 

    Examines the barriers to delivery of intravenous thrombolysis treatment for patients with acute ischemic stroke. Challenges facing clinicians and health service providers in administering the thrombolysis treatment; Components of care for acute stroke.

  • Can the time window for administration of thrombolytics in stroke be increased? Donnan, Geoffrey A.; Howells, David W.; Markus, Rornesh; Toni, Danilo; Davis, Stephen M.; Markus, Romesh // CNS Drugs;2003, Vol. 17 Issue 14, p995 

    Level 1 evidence now shows that thrombolysis in cases of acute ischaemic stroke is effective if administered within 3 hours of stroke onset. This benefit has been shown to be time dependent and potentially extends beyond 3 hours, with evidence that potentially viable penumbral tissue may be...

  • Grenzentscheidungen in der Schlaganfalltherapie. Endres, M.; Grond, M.; Hacke, W.; Ebinger, M.; Schellinger, P.D.; Dichgans, M. // Der Nervenarzt;Aug2011, Vol. 82 Issue 8, p957 

    In numerous situations stroke physicians face a lack of evidence during their daily practice. In this report the authors address some of the difficult treatment decisions encountered in acute therapy and secondary prevention. Examples include off-label thrombolysis and prevention in high-risk...

  • FINESSE: Study results could bring an end to facilitated PCI following ST-elevation myocardial infarction.  // Formulary;Oct2007, Vol. 42 Issue 10, p609 

    The article focuses on a study delivered at the 2007 congress of the European Society of Cardiology in Vienna, Austria. Results of the research demonstrated that thrombolytic therapy with reteplase/abciximab before percutaneous coronary intervention (PCI) has no effect on post-myocardial...

  • Cardiology's 10 Greatest Discoveries of the 20th Century. Mehta, Nirav J.; Khan, Ijaz A. // Texas Heart Institute Journal;2002, Vol. 29 Issue 3, p164 

    We present a brief summary of the 10 greatest cardiologic developments and discoveries of the 20th century. Described are electrocardiography,' preventive cardiology and the Framingham Study,' 'lipid hypotheses' and atherosclerosis; coronary care units; echocardiography; thrombolytic therapy,'...

  • Efficacy of intra-arterial thrombolysis for acute ischemic stroke. Meta-analysis of randomized controlled trials. Fink, Matthew E. // Neurology Alert;Jun2010, Vol. 28 Issue 10, p79 

    The article discusses research on the effectiveness of intra-arterial thrombolysis for patients with acute ischemic stroke, referencing a study by M. Lee and colleagues, published in the 2010 issue of "Stroke."

  • JournalScan. Malik, Iqbal // Heart;Jun2002, Vol. 87 Issue 6, p590 

    This article presents research results related to heart disease. In a cohort of over 2000 patients, more than 75 years old who had a myocardial infarction, only 63% of eligible patients got thrombolysis while 27% of thrombolysis recipients had what are regarded as absolute contraindications to...

  • CORONARY ARTERY DISEASE -- DRUG USE.  // Current Medical Literature: Interventional Cardiology Monitor;2004, Vol. 11 Issue 1, p26 

    Discusses articles on drug use in coronary artery disease that have been published in various journals as of April 2004. "Transfer for primary angioplasty versus immediate thrombolysis in acute myocardial infarction: a meta-analysis," by M. Dalby, et al; "A comparison of coronary angioplasty...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics