Somatostatin and Peripheral Blood Flow in Man

Savi, Luigi; Cardillo, Carmine; Bombardieri, Giuseppe
August 1985
Angiology;Aug1985, Vol. 36 Issue 8, p511
Academic Journal
Somatostatin (SS), a physiological substance which inhibits secretion of GH, TSH, glucagon and insulin, was evaluated as a vasoactive agent. In normal and arteriopatic subjects SS was administered intravenously by bolus for 3 minutes and by infusion for 30 minutes. Rheography and plethysmography of lower limbs were performed before, during and after somatostatin administration. A marked improvement of blood flow, provoked by somatostatin, was observed. A reduction of heart rate was also observed. Some hypotheses about the mechanism with which SS acts upon peripheral circulation are discussed.


Related Articles

  • Effects of Somatostatin Prophylaxis after Pylorus-preserving Pancreaticoduodenectomy: Increased Delayed Gastric Emptying and Reduced Plasma Motilin. Yan-Shen Shan; Sy, Edgar D.; Mei-Ling Tsai; Li-Ying Tang; P. Shirley Li; Pin-Wen Lin // World Journal of Surgery;Oct2005, Vol. 29 Issue 10, p1319 

    Somatostatin inhibits gastroenteropancreatic exocrine secretion and is often used after pancreaticoduodenectomy to reduce pancreatic secretion to minimize tissue damage and pancreatic slump complications. Because our earlier clinical work saw a major increase in delayed gastric emptying (DGE)...

  • Somatostatin receptors in the ventral pallidum/substantia innominata modulate rat locomotor activity. Marazioti, A.; Kastellakis, A.; Antoniou, K.; Papasava, D.; Thermos, K. // Psychopharmacology;Sep2005, Vol. 181 Issue 2, p319 

    Rational: Somatostatin and its receptors (sst1 and sst2) have been localized in brain nuclei implicated in motor control, such as the nucleus accumbens, ventral pallidum (VP) and substantia innominata (SI). Objectives: The objective of the study is to investigate the effect of somatostatin and...

  • Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic α-cells. Gromada, Jesper; Høy, Marianne; Olsen, Hervør L.; Gotfredsen, Carsten F.; Buschard, Karsten; Rorsman, Patrik; Bokvist, Krister // Pflugers Archiv European Journal of Physiology;Apr2001, Vol. 442 Issue 1, p19 

    Somatostatin hyperpolarized rat pancreatic α-cells and inhibited spontaneous electrical activity by activating a low-conductance K+ channel (0.9 pS with physiological ionic gradients). This channel was insensitive to tolbutamide (a blocker of ATP-sensitive K+ channels) and apamin (an...

  • Functional characterisation of the putative somatostatin sst2 receptor antagonist CYN 154806. Nunn, Caroline; Schoeffter, Philippe; Langenegger, Daniel; Hoyer, Daniel // Naunyn-Schmiedeberg's Archives of Pharmacology;Jan2003, Vol. 367 Issue 1, p1 

    The two forms (DTyr8 and LTyr8) of the putative somatostatin sst2 receptor antagonist CYN 154806 (Ac-4NO2-Phe-c(DCys-Tyr-DTrp-Lys-Thr-Cys)-D/LTyr-NH2) were investigated on recombinant human somatostatin receptors and endogenous guinea-pig ileum receptors. In radioligand binding studies using the...

  • Insights into Structure-Activity Relationships of Somatostatin Analogs Containing Mesitylalanine. Martín-Gago, Pablo; Aragón, Eric; Gomez-Caminals, Marc; Fernández-Carneado, Jimena; Ramón, Rosario; Martin-Malpartida, Pau; Verdaguer, Xavier; López-Ruiz, Pilar; Colás, Begoña; Cortes, María Alicia; Ponsati, Berta; Macias, Maria J.; Riera, Antoni // Molecules;Dec2013, Vol. 18 Issue 12, p14564 

    The non-natural amino acid mesitylalanine (2,4,6-trimethyl-L-phenylalanine; Msa) has an electron-richer and a more conformationally restricted side-chain than that of its natural phenylalanine counterpart. Taking these properties into account, we have synthesized ten somatostatin analogs...

  • Somatostatin for intractable postoperative chylothorax in a premature infant. Clarke, S.; Lakhoo, K.; Sherwood, W.; Clarke, S A // Pediatric Surgery International;May2005, Vol. 21 Issue 5, p390 

    A premature infant of 31 weeks' gestation underwent repair of an oesophageal atresia, distal tracheo-oesophageal fistula and anal stenosis. A lymphatic leak was noted at the time of surgery. Chylous drainage persisted and an intravenous infusion of somatostatin was begun. The volume of chyle...

  • Clinical applications of somatostatin analogs for growth hormone-secreting pituitary adenomas. Ji-wen Wang; Ying Li; Zhi-gang Mao; Bin Hu; Xiao-bing Jiang; Bing-bing Song; Xin Wang; Yong-hong Zhu; Hai-jun Wang // Patient Preference & Adherence;2014, Vol. 8, p43 

    Excessive growth hormone (GH) is usually secreted by GH-secreting pituitary adenomas and causes gigantism in juveniles or acromegaly in adults. The clinical complications involving cardiovascular, respiratory, and metabolic systems lead to elevated morbidity in acromegaly. Control of serum GH...

  • SSTR1 and SSTR5 subtypes are the dominant forms of somatostatin receptor in neuroendocrine tumors. Pisarek, Hanna; Pawlikowski, Marek; Kunert-Radek, Jolanta; Kubiak, Robert; Winczyk, Katarzyna // Folia Histochemica et Cytobiologica;2010, Vol. 48 Issue 1, p142 

    The effectiveness of the long acting somatostatin analogues like octreotide and lanreotide depends on the expression of specific somatostatin receptors on the target cells. The immunohistochemical method performed on surgically removed tumors searches the expression of receptors at the level of...

  • In vivo inhibition of the rat primary antibody response to antigenic stimulation by somatostatin. Eglezos, Anthony; Andrews, Paul V.; Helme, Robert D. // Immunology & Cell Biology;Apr1993, Vol. 71 Issue 2, p125 

    Somatostatin inhibits in vitro lymphocyte proliferative responses from a variety of species including human, mouse and rat. The immunoinhibitory effects of somatostatin are thought to involve binding to specific cell surface .somatostatin receptors on immunocompetent cells. This report describes...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics