Lippmann, Heinz I.
October 1957
Angiology;Oct1957, Vol. 8 Issue 5, p378
Academic Journal
1. Twenty-three cases of subcutaneous ossification in the legs were described. One leg was involved in 15, both in 8 cases. 2. All patients were women in the menopause, suffering from chronic venous insufficiently in the involved extremities. Edema of dependency and chronic cellulitis were always present. 3. There was no evidence of systemic disturbances of calcium metabolism. No extraskeletal bone formation was encountered outside the lower extremities. 4. The diagnosis was established by palpation and roentgenography, and in 4 cases was corroborated by histopathologic study of removed specimen which contained cancellous heterotopic bone. Soft tissue calcification in non-osseous tissue was not seen. 5. The condition, which hitherto has been unrecognized, probably has a high incidence in the general population, especially in its less extensive forms. 6. The influence of chronic intermittent trauma, of chronic inflammation, of blood extravasation into skin and subcutaneous tissue, of sex and hormonal imbalance upon extraskeletal bone formation was discussed.


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