TITLE

Effects of Mesoglycan Sulfate on the Arterial Elastic Module

AUTHOR(S)
Andreozzi, Guiseppe Maria; Signorelli, Salvalore; Lo Duca, Salvatrice; Minacapelli, Concetta; Amico-Roxas, Maria T.; Minardo, Giovanna; Cacciaguerra, Giuseppe
PUB. DATE
August 1987
SOURCE
Angiology;Aug1987, Vol. 38 Issue 8, p593
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Ten patients with peripheral obstructive arterial disease (POAD) in stages I and II according to Leriche-Fontaine, were subjected to therapy with mesoglycan sulfate (60 mg/day for twenty days), to evaluate the effect of the drug on the elastic module of the arterial wall. The wall elasticity was deduced from some Doppler velocitographic indices (arterial dynamics index, resistance index, perfusion pressure index, tibial distensibility index); from the analysis of systolic, protodiastolic, and end diastolic velocity variations; and from computerized analysis of the Doppler sound spectrum. The results show a significant improvement of arterial wall elasticity, which suggests a rational use for the drug in the initial stages of peripheral obstructive arterial disease.
ACCESSION #
16352015

 

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