Nakamura, Takashi; Nakamura, Shozo; Aikawa, Tatsuya; Suzuki, Osama; Onodera, Atsushi; Iida, Hiroyoshi
June 1971
Angiology;Jun1971, Vol. 22 Issue 6, p344
Academic Journal
After a mixed solution of D-galactose-1-C14, T-1824 dye, and serum of a patient was injected into the superior vena cava or into the peripheral vein, blood was sampled from the brachial artery and from the hepatic vein. From the radioactivities and the dye concentrations of the arterial blood and the hepatic venous blood, per cent intrahepatic shunt was calculated. Per cent intrahepatic shunt calculated by this method in 8 controls with normal liver was 4–20 per cent. Six patients with acute viral hepatitis showed 0–22 per cent of intrahepatic shunt. Thus, determination of the intrahepatic shunted blood flow by the D-galactose-1-C14 method seems to be little influenced by acute hepatic injury. By this method, moreover, the intrahepatic shunted blood flow could be measured more simply and more precisely than the galactose method reported previously. Per cent intrahepatic shunt of 35 patients with chronic viral hepatitis was 10–55 per cent. Similar slight increases of per cent intraliepatic shunt was also observed in other kinds of hepatic fibrosis. Per cent intrahepatic shunt of 25 patients with hepatic cirrhosis was 23–87 per cent. There was statistically significant correlation between per cent intrahepatic shunt and per cent of interstitial tissue in hepatic biopsy specimens of the cirrhotic patients. Measurement of intrahepatic shunted blood flow by means of D-galactose-1-C14 is useful for diagnosis of hepatic diseases, especially hepatic cirrhosis and hepatic fibrosis.


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